Evidence map›Paper›PMID 41846966›Full record

ArticlebioRxiv : the preprint server for biology2026

Granule cells reorient cortical manifolds to separate contexts but preserve their geometry.

Martha G Garcia-Garcia, Michał J Wójcik, Srijan Thota, Luke Drake, Amma Otchere, Oluwatobi Akinwale, Lizmaylin Ramos, Rui Ponte Costa, Mark J Wagner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Martha G Garcia-GarciaNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-3945-1944
Michał J WójcikDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Srijan ThotaNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD 20894, USA.
Luke DrakeNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD 20894, USA.
Amma OtchereNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD 20894, USA.
Oluwatobi AkinwaleNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD 20894, USA.
Lizmaylin RamosNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD 20894, USA.
Rui Ponte CostaDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID 0000-0003-2595-2027
Mark J WagnerNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-1816-6407

Funding

Neocortex-cerebellum Circuitry Unit ZIANS009434 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WAGNER, MARK · 2022 to 2025
$8.8M
Intramural NIH HHS ZIA NS009434
6 · The paper itself

Abstract

To learn effectively, animals must generalize across yet distinguish between related contexts. Generalization relies on low-dimensional neural manifolds found throughout neocortex

Identifiers

PMID41846966
PMCPMC12991086

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.