Evidence map›Paper›PMID 41846959›Full record

ArticlebioRxiv : the preprint server for biology2026

Xylazine's κ opioid agonist activity is not shared with other FDA-approved α

Xi-Ping Huang, Brian E Krumm, Madigan L Bedard, Zoe A McElligott, Bryan L Roth

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xi-Ping HuangDepartment of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27510.
Brian E KrummDepartment of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27510.
Madigan L BedardBowles Center for Alcohol Studies, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27510.
Zoe A McElligottDepartment of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27510.
Bryan L RothDepartment of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27510.ORCID 0000-0002-0561-6520

Funding

TO AWARD THE BASE PERIOD FOR NIMH PSYCHOACTIVE DRUG SCREENING PROGRAM (PDSP). BASE POP: 08/30/2023-08/29/2024.75N95023C00021 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROTH, BRYAN · 2023 to 2025
$9.0M
An informatics approach to examine genetic and environmental regulation of the PI3K-AKT-mTOR pathway in autism spectrum disorderF31MH122205 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TESSEMA, KALEAB KIDANE · 2020 to 2022
$136k
FDA HHS U01 FD007857NIH HHS 75N95023C00021NIMH NIH HHS F31 MH122205
6 · The paper itself

Abstract

Xylazine is a α

Identifiers

PMID41846959
PMCPMC12991102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.