Evidence map›Paper›PMID 41846956›Full record

ArticlebioRxiv : the preprint server for biology2026

Hierarchical membrane-chromatin tethering buffers nuclear envelope assembly against alterations in lipid flux.

Sarah R Barger, Sofia Sepúlveda, Han Yang, Marc Goudge, Shoken Lee, Neale D Ridgway, Shirin Bahmanyar

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah R BargerDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-6941-7256
Sofia SepúlvedaDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Han YangDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Marc GoudgeDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-0339-7520
Shoken LeeDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-6410-1826
Neale D RidgwayDepartment of Pediatrics and Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2.ORCID 0000-0002-0441-6228
Shirin BahmanyarDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-6583-5055

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Defining the role of lipid metabolism in nuclear envelope identity and dynamicsR01GM131004 · NIGMS · YALE UNIVERSITY · PI Shirin Bahmanyar · 2019 to 2026
$2.8M
NIGMS NIH HHS R01 GM131004NIH HHS P40 OD010440
6 · The paper itself

Abstract

In open mitosis, a single nuclear envelope (NE) forms around segregated chromosomes despite an excess of membrane-chromatin tethers. Here, we identify a hierarchical relationship between the BAF binding membrane tethers LEM-2 and Emerin, in which LEM-2 preferentially accumulates at BAF binding sites during postmitotic NE assembly and limits Emerin accumulation in

Identifiers

PMID41846956
PMCPMC12991105

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.