Evidence map›Paper›PMID 41846945›Full record

ArticlebioRxiv : the preprint server for biology2026

Linking cross-species trajectories of cerebrovascular remodeling in aging and Alzheimer's disease to brain vessel transcriptome.

Noah Schweitzer, Yucheng Shen, Yifan Zhao, Christopher Cover, Shahnur Alam, Rebecca Deek, Jiatai Li, George Stetten, Howard Aizenstein, Minjie Wu and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Noah SchweitzerDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Yucheng ShenDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Yifan ZhaoDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Christopher CoverDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Shahnur AlamDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, United States of America.
Rebecca DeekDepartment of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, PA, United States of America.
Jiatai LiDepartment of Computer Science, Carnegie Mellon University, Pittsburgh, PA, United States of America.
George StettenDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Howard AizensteinDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Minjie WuDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Rada KoldamovaDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, United States of America.
Alberto VazquezDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Nicholas F FitzDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, United States of America.
Bistra IordanovaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

Funding

Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
ncRNAs in plasma EVs of AD patients and their discriminatory power as biomarkersRF1AG075992 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLDAMOVA, RADOSVETA, LEFTEROV, ILIYA · 2022 to 2025
$3.7M
The interplay between Tau and ncRNAs – genomic and epigenomic clues to early AD pathogenesisR01AG077636 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOSVETA KOLDAMOVA, ILIYA LEFTEROV · 2022 to 2026
$3.5M
Neurodevelopmental and neurodegenerative effects of environmental determinants: altering neural cellular populations impacting homeostatic functions and inflammatory response.R01AG075069 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FITZ, NICHOLAS FRANCIS · 2021 to 2025
$2.8M
Neurovascular and metabolic sex differences in contributions to cognitive impairment and dementia including Alzheimer's diseaseRF1NS116450 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI IORDANOVA, BISTRA · 2020 to 2020
$2.6M
7T Vascular and Molecular Imaging of SVD: Sex, Equol, and Risk of Alzheimer’s DiseaseR01AG085566 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, AKIRA SEKIKAWA · 2024 to 2026
$2.1M
Bioengineering in Psychiatry Training ProgramT32MH119168 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, IBRAHIM, TAMER S · 2019 to 2023
$1.1M
Multiscale Models of Age-Specific Neurometabolic CouplingR01AG092661 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bistra Iordanova, LIANG ZHAN · 2026 to 2026
$665k
NHLBI NIH HHS T32 HL076124NIA NIH HHS R01 AG075069NIA NIH HHS R01 AG077636NIA NIH HHS R01 AG085566NIA NIH HHS R01 AG092661NIA NIH HHS RF1 AG075992NIMH NIH HHS T32 MH119168NINDS NIH HHS RF1 NS116450
6 · The paper itself

Abstract

Cerebrovascular remodeling driven by subtle molecular changes starts early in the asymptomatic stage of Alzheimer's disease (AD). Despite progress in human vascular imaging and

Identifiers

PMID41846945
PMCPMC12991082

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.