Evidence map›Paper›PMID 41846938›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural adaptations for enhanced translation kinetics in evolved ribosomes.

Tushar Raskar, Alan Costello, Ahmed H Badran, James S Fraser

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Tushar RaskarDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158.ORCID 0000-0001-7188-7428
Alan CostelloDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0002-6266-5070
Ahmed H BadranDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0002-8105-1883
James S FraserDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158.ORCID 0000-0002-5080-2859

Funding

Equipment for Discovering and Manipulating Macromolecular Conformational EnsemblesR35GM145238 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James Solomon Fraser · 2022 to 2026
$3.1M
Functional Interrogation Of Ribosomal Biology Using Continuous EvolutionDP5OD024590 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI BADRAN, AHMED HUSSEIN · 2017 to 2021
$2.2M
NIGMS NIH HHS R35 GM145238NIH HHS DP5 OD024590
6 · The paper itself

Abstract

The ribosomal RNA sequence governs translation dynamics, yet understanding how changes beyond the conserved catalytic centers influence kinetics and protein yield remains limited. Using orthogonal ribosome phage-assisted continuous evolution (oRibo-PACE), we recently reported chimeric ribosomes derived from

Identifiers

PMID41846938
PMCPMC12991084

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.