Evidence map›Paper›PMID 41846936›Full record

ArticleFrontiers in immunology2026

Host biological sex directs immune control of the

Caroline J Duncombe, Alen S Poehlman, Ethan N Conrad, Nilasha Sen, Aaron Ayenew, Rebecca C Blyn, G W McElfresh, Elizabeth K K Glennon, Kenneth Boey, Anya C Kalata and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Caroline J DuncombeGraduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA, United States.
Alen S PoehlmanCenter for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, WA, United States.
Ethan N ConradDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Nilasha SenDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Aaron AyenewCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Rebecca C BlynGraduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA, United States.
G W McElfreshOregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, United States.
Elizabeth K K GlennonCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Kenneth BoeyDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Anya C KalataDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Alexis KaushanskyCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Nana MinkahCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Melanie J ShearsDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Sean C MurphyGraduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA, United States.

Funding

Impairment of anti-Plasmodium T cell memory by type I Interferon SignalingR01AI170777 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Nana Kwaku Minkah · 2023 to 2026
$3.2M
NIAID NIH HHS R01 AI170777
6 · The paper itself

Abstract

Introduction: Methods: Male and female BALB/cJ mice, including orchiectomized (ORX) and androgen-treated males, were infected with Results: Androgens increased parasite survival by reducing elimination of parasite-infected hepatocytes. Females and ORX males exhibited enhanced immune activity during Discussion: These findings indicate that biological sex- and androgen-mediated differences in baseline hepatic innate immune cell composition critically shape immune responses and parasite survival during

Indexed as

Host-Parasite InteractionsLiverMalariaPlasmodium yoeliiAndrogensAnimalsFemaleHepatocytesKupffer CellsMaleMiceMice, Inbred BALB CSex CharacteristicsSex FactorsAndrogensandrogeninnate immunityKupffer celllivermalariaPlasmodiumsex differencestestosterone

Identifiers

PMID41846936
PMCPMC12989532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.