Evidence map›Paper›PMID 41846931›Full record

ArticleFrontiers in immunology2026

Macrophage-derived CCL20 promotes abdominal aortic aneurysm progression via lymphocytes CCR6.

Qingnan Ren, Tianyong Sun, Song Shen, Yuanbin Cao, Li Wei, Yang Zhao, Fengxin Wan, Ping Sui, Ke Xiao, Hao Bai and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Qingnan RenDepartment of Vascular Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Tianyong SunDepartment of Health Care (Department of General Dentistry II), Human Microbiome, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Song ShenDepartment of Health Care (Department of General Dentistry II), Human Microbiome, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Yuanbin CaoDepartment of Vascular Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Li WeiDepartment of Health Care (Department of General Dentistry II), Human Microbiome, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Yang ZhaoDepartment of Vascular Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Fengxin WanDepartment of Vascular Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Ping SuiDepartment of Vascular Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Ke XiaoDepartment of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Hao BaiClinical Epidemiology Unit, Department of Nutrition, Clinical Research Center of Shandong University, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Dachuan GuoDepartment of Cardiology, State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Qi HeDepartment of Health Care (Department of General Dentistry II), Human Microbiome, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Mengfan ZhiDepartment of Health Care (Department of General Dentistry II), Human Microbiome, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Jianmin YangDepartment of Cardiology, State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Jianjun JiangDepartment of Vascular Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Wencheng ZhangDepartment of Cardiology, State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Xiangjiu DingDepartment of Vascular Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Abdominal aortic aneurysm (AAA) is a chronic vascular disease marked by chronic inflammation and immune dysregulation. The C-C motif chemokine ligand 20 (CCL20) - C-C motif chemokine receptor type 6 (CCR6) axis modulates immune responses in vascular diseases, but its role in AAA remains unclear. This study investigates the involvement of the CCL20-CCR6 axis in AAA formation. Methods: Single-cell RNA sequencing datasets and bulk RNA sequencing datasets were analyzed to assess cellular composition and transcriptional changes. Transcriptomic analysis, enzyme-linked immunosorbent assay, UK Biobank database analysis, CellChat analysis, immunofluorescence staining, and mouse models were employed to explore the CCL20-CCR6 axis in AAA. Results: Substantial immune cell infiltration (T lymphocytes & B lymphocytes) and loss of structural cells (fibroblasts, endothelial cells and smooth muscle cells) were identified using single-cell RNA sequencing datasets. Macrophage polarization was imbalanced, with enriched M1-like macrophages and elevated CCL20 secretion. Macrophages could promote the formation of AAA by recruiting a large number of immune cells via the CCL20-CCR6 axis. Conclusions: Macrophage-derived CCL20 aggravates lymphocyte recruitment via the CCR6, promoting AAA progression. CCL20 may serve as a biomarker for AAA. Targeting the CCL20-CCR6 axis could inhibit immune recruitment and AAA progression.

Indexed as

Aortic Aneurysm, AbdominalChemokine CCL20LymphocytesMacrophagesReceptors, CCR6AnimalsDisease Models, AnimalDisease ProgressionHumansMaleMiceMice, Inbred C57BLCCL20 protein, humanCCL20 protein, mouseCCR6 protein, humanCCR6 protein, mouseChemokine CCL20Receptors, CCR6abdominal aortic aneurysmCCL20-CCR6 axisC-C motif chemokine ligand 20C-C motif chemokine receptor 6vascular disease

Identifiers

PMID41846931
PMCPMC12989375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.