ArticleThe British journal of cardiology2024
SGLT2 inhibitors: between the zeal of the clinical studies and the challenges of the day-to-day practice.
Article in The British journal of cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) have demonstrated efficacy in reducing cardiovascular deaths and hospitalisations associated with heart failure patients. Despite well-established benefits observed in clinical trials, their real-world application remains underexplored. The purpose of this quality improvement project was to investigate and address the gap between evidence-based guidelines and the practical application of SGLT2i therapy in patients with heart failure with reduced ejection fraction (HFrEF). The medical records were assessed in retrospect for HFrEF-related admissions at our cardiac centre. The main target of assessment was the dapagliflozin prescriptions in eligible patients. After the first cycle of data collection and analysis, several interventions, in the form of targeted teaching, empowering pharmacists, and utilising digital tools, were employed to improve compliance with prescriptions. After the implementation of our measures, a further cycle of data collection and analysis was carried out. In the first cycle, 31% of 225 HFrEF patients, aged 74 ± 15 years, received dapagliflozin or had plans for its initiation. Prescription rates were influenced by age (mean 69
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