ArticleJournal of pharmacy & bioallied sciences2025
Altered Bone Geometry and Quality in Type 2 Diabetes Mellitus: Insights from Peripheral Quantitative Computed Tomography in an Indian Cohort.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Type 2 Diabetes Mellitus (T2DM) is increasingly recognized as a risk factor for skeletal fragility, independent of bone mineral density (BMD). Objective: This prospective, cross-sectional case-control study investigated bone geometry using peripheral quantitative computed tomography (pQCT) in 100 patients with T2DM. Methodology: 100 cases of Type 2 DM and healthy cohorts were compared for bone geometry at a tertiary care hospital. Results: Trabecular density was notably reduced in men, while both periosteal and endosteal circumferences were significantly diminished in both sexes, suggesting cortical thinning and compromised bone geometry. Conclusion: The findings suggest that pQCT provides valuable insights into microarchitectural deficits, explaining the increased fracture risk in T2DM.
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