ArticleJournal of pharmacy & bioallied sciences2025
Exploring Alternative Fluoride Agents for Dental Caries Prevention: A Systematic Review.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dental caries remains a widespread global health challenge, prompting the exploration of alternative fluoride agents. This systematic review evaluates the efficacy of nano-silver fluoride (NSF), silver diamine fluoride (SDF), titanium tetrafluoride (TiF4), and sodium fluoride varnish (NaF) in caries prevention and arrest. Methods: A systematic search of PubMed, Scopus, and Web of Science was conducted to identify studies published between 2010 and 2024. Inclusion criteria focused on randomized controlled trials, clinical studies, and in vitro investigations comparing alternative fluoride agents. Data on caries arrest rates, enamel remineralization, biofilm inhibition, and adverse effects were extracted and analyzed. Results: NSF demonstrated superior enamel microhardness and reduced microleakage without staining. SDF showed high caries arrest rates (95-98%) but caused black staining of treated lesions. TiF4 effectively increased acid resistance and reduced biofilm activity, outperforming NaF in specific applications. NaF, while cost-effective and widely accessible, was less effective for advanced caries compared to SDF and NSF. Conclusion: Alternative fluoride agents, such as NSF and TiF4, offer promising results in caries prevention and management, addressing limitations of traditional fluoride treatments. Further clinical trials are needed to validate these findings for broader implementation.
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