ArticleJournal of pharmacy & bioallied sciences2025
Comparison of Postoperative Oxygen Saturation After Intraperitoneal Ropivacaine 0.375% Versus Placebo in Laparoscopic Abdominal Surgery.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Aim: Present study was designed to compare intraperitoneal ropivacaine 0.375% with placebo in patients undergoing laparoscopic abdominal surgery, evaluating not only analgesic outcomes but also postoperative oxygen saturation to better define its safety and clinical utility. Material and Methods: This randomized, double-blind controlled study was conducted on 80 ASA I-II patients undergoing elective laparoscopic abdominal surgery, divided equally into two groups receiving either 40 mL of ropivacaine 0.375% or 40 mL of normal saline intraperitoneally at the end of surgery. Oxygen saturation, pain intensity, and rescue analgesic requirements were monitored for 24 hours. Results: The placebo group consistently showed marginally higher oxygen saturation than the ropivacaine group, with differences statistically significant but not clinically relevant. Patients receiving ropivacaine had significantly prolonged analgesia and reduced need for rescue analgesics without additional adverse events. Conclusion: The findings support intraperitoneal ropivacaine as a safe and effective adjunct in multimodal analgesia for laparoscopic surgery, with minimal influence on oxygen saturation.
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