ArticleERJ open research2026
Utility of hyperpolarised xenon-129 magnetic resonance imaging in primary ciliary dyskinesia.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pulmonary Exacerbations and Treatment in PCD: A Narrative Review.Pediatric pulmonology · 2026Review
- Xenon-129 magnetic resonance: a paradigm shift, an expensive toy or another tool for the pulmonologist?ERJ open research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Managing patients with primary ciliary dyskinesia (PCD) is challenging due to limited therapeutic options and lack of sensitive, disease-specific outcome measures. Hyperpolarised 129-xenon magnetic resonance imaging (Xe MRI) is an emerging imaging modality that quantifies ventilation heterogeneity using the ventilation defect per cent (VDP). In other obstructive lung diseases, VDP has demonstrated increased sensitivity compared to conventional lung function measures; however, its utility in PCD has not been established. In PCD, we aimed to: 1) determine the feasibility of Xe MRI; 2) evaluate the same-day repeatability of VDP; and 3) explore the relationship between VDP with lung clearance index 2.5% (LCI Methods: In this cross-sectional observational study, participants >6 years old with confirmed PCD were recruited from two Canadian PCD centres. Participants underwent lung function testing to measure FEV Results: 16 participants completed the study. In all participants, the VDP was elevated (VDP>2.3) with a median VDP of 11.05% (IQR: 4.83-13.67%). Same-day repeat Xe MRI VDP had an ICC>0.95 and B&A showed good agreement. VDP positively correlated with LCI Conclusions: Xe MRI is a feasible imaging modality to capture lung disease in PCD. VDP has excellent same-day repeatability and correlated strongly with LCI
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.