ArticleCureus2026
Gallbladder Adenocarcinoma With Metastasis in a Young Patient Without Traditional Risk Factors.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gallbladder cancer (GBC) is an aggressive malignancy with a poor prognosis, often diagnosed incidentally or at an advanced stage. We describe a case of gallbladder carcinoma in a 30-year-old female presenting with a two-week history of upper abdominal pain radiating to the back, bloating, and excessive gas. Laboratory evaluation showed markedly elevated carcinoembryonic antigen levels, and MRI demonstrated a polypoidal gallbladder fundal mass without evidence of gallstones. The patient underwent laparoscopic cholecystectomy, and histopathology confirmed biliary-type adenocarcinoma and evidence of metastasis. Postoperatively, she was diagnosed with stage IV disease and started on systemic therapy with pembrolizumab, gemcitabine, and cisplatin. After three cycles, PET/CT revealed complete metabolic resolution of metastases, with normalization of tumor markers. This case highlights that GBC can occur in young patients and may present at advanced stages even in the absence of gallstones, emphasizing the importance of early suspicion when evaluating gallbladder masses and the potential effectiveness of combined chemo-immunotherapy in achieving meaningful responses.
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