Trial reportJournal of pain research2026
Tuina Alleviates Pain Associated with Lumbar Disc Herniation by Regulating Functional Connectivity Between Inferior Frontal Triangularis and Multiple Brain Networks: A Randomized Controlled fMRI Study.
Trial report in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Efficacy and Safety of CT-Verified Deep Needling at the Foramen Acupoint for Lumbar Disc Herniation: A Randomized Controlled Trial.Pain research & management · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study conducted a randomized controlled trial by analyzing resting-state functional magnetic resonance imaging (rs-fMRI) data to determine the mechanisms by which Tuina alleviates pain and modulates multiple brain networks in lumbar disc herniation (LDH) patients. Patients and Methods: This study included 38 healthy subjects and 76 LDH patients. LDH patients were randomly assigned into the test group (TG; n = 38) and control group (CG; n = 38). TG patients received 14 days of Tuina therapy, whereas CG patients received a combination of transcutaneous electrical nerve stimulation (TENS) and lumbar traction therapy. The primary outcome measure, simplified McGill Pain Questionnaire (SF-MPQ), was used to assess pain. Pain pressure threshold (PPT), Oswestry Disability Index (ODI), Beck Depression Inventory II (BDI-II), and Beck Anxiety Inventory (BAI) were evaluated as secondary outcomes. Fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) values were evaluated from the rs-fMRI data before and after treatment. Results: The SF-MPQ score significantly decreased in both TG subjects [-13.00 (-19.00, -9.00); Conclusion: Tuina effectively alleviates pain, lumbar dysfunction, and negative emotions in LDH patients by regulating the interactions between multiple neural networks in the brain, especially through the inferior frontal gyrus triangle area.
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Registered trials
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