SynthesisThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2025
Optimal Timing of Endoscopic Intervention for Acute Variceal Bleeding in Cirrhotic Patients: A Systematic Review and Meta-Analysis.
Synthesis in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute variceal bleeding (AVB) is a severe complication in cirrhotic patients. The optimal timing for endoscopic treatment remains uncertain.
methodsA systematic search of PubMed, Embase, and the Cochrane Library was conducted. Outcomes included mortality, rebleeding rate, number of red blood cells (RBC) transfused, length of hospitalization, and other clinical endpoints. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Meta-analysis was performed using RevMan 5.4.1 (Cochrane, Oxford, United Kingdom) and Stata 18.0 (StataCorp LLC, College Station, United States), with subgroup, sensitivity, and publication bias analyses.
resultsNo significant differences were observed between early and delayed endoscopy groups for the outcomes. However, in-hospital mortality was higher in the early endoscopy group (odds ratio (OR) = 1.55, 95% CI: 0.92-2.61, P = .10) and reached significance in sensi tivity analysis (OR = 1.76, 95% CI: 1.02-3.04, P = .04). Additionally, the early group tended to reduce the 6-week bleeding rate (OR = 0.78; 95% CI: 0.49-1.33; P = .4) and reached significance in sensitivity analysis (OR = 0.63, 95% CI: 0.43-0.92, P = .02). Moreover, the early group tended to require fewer RBC transfusions (mean difference (MD) = -0.62, 95% CI: -1.33 to 0.09, P = .09), confirmed in subgroup analysis (MD = -1.32, 95% CI: -2.41 to -0.24, P = .02).
conclusionNo significant differences were found between groups for outcomes. However, subgroup or sensitivity analysis revealed that early endoscopy may increase in-hospital mortality, while reducing 6-week rebleeding and RBC transfusion. Further randomized trials are needed to confirm these findings. Cite this article as: Jiang Y, Lu Y, Wang Y. Optimal timing of endoscopic intervention for acute variceal bleeding in cirrhotic patients: A systematic review and meta-analysis. Turk J Gastroenterol. 2026;37(3):281-291.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.