Evidence map›Paper›PMID 41846281›Full record

ArticleFEBS open bio2026

Evolutionarily divergent DUF4465 domains have a common vitamin B

Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J Warren, Richard W Pickersgill

Abstract read
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Charlea ClarkeSchool of Biological and Behavioural Sciences, Queen Mary University of London, UK.ORCID https://orcid.org/0009-0004-5029-0090
Michal BanasikSchool of Biological and Behavioural Sciences, Queen Mary University of London, UK.
Rokas JuodeikisQuadram Institute Biosciences, Norwich, UK.
Martin J WarrenQuadram Institute Biosciences, Norwich, UK.
Richard W PickersgillSchool of Biological and Behavioural Sciences, Queen Mary University of London, UK.ORCID https://orcid.org/0000-0001-6600-2381

Funding

Biotechnology and Biological Sciences Research Council Grant BB/X001946/1
6 · The paper itself

Abstract

The DUF4465 family (DUF, domain of unknown function) contains more than 1000 members distributed across eight bacterial clades with species from diverse microenvironments including various gut microbiomes, hydrothermal vents, and soil. In the gut commensal Bacteroides thetaiotaomicron (B. theta), DUF4465 containing proteins act as high-affinity B

Indexed as

Bacterial ProteinsVitamin B 12BacteroidesBinding SitesEvolution, MolecularPhylogenyProtein BindingProtein DomainsBacterial ProteinsVitamin B 12B12‐binding proteinsB12‐scavenging proteinsDUF4465 (DUF Domain of Unknown Function)IPR027828 family proteinsmicrobiomeβ‐jellyroll proteins

Identifiers

PMID41846281
PMCPMC13398666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.