ArticleJournal of pediatric endocrinology & metabolism : JPEM2026
Volumetric MRI assessment of brain and pituitary structure in girls with central precocious puberty.
Article in Journal of pediatric endocrinology & metabolism : JPEM, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Development and validation of diagnostic prediction models for central precocious puberty in girls based on machine learning: a multicenter retrospective study.Frontiers in endocrinology · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare global and regional brain volumes and pituitary morphology between girls with central precocious puberty (CPP) and age-matched controls using intracranial-volume (ICV)-adjusted magnetic resonance imaging (MRI), and to assess associations between gonadotropins and brain volumetry.
methodsThis retrospective study included 182 girls (CPP n=91; controls n=91; age 6-9 years at MRI acquisition). Brain MRI (1.5 T) was segmented using the volBrain pipeline, and global and regional volumes were normalized to ICV. Pituitary height and volume were measured by two blinded radiologists. Group differences were analyzed with Welch
resultsCPP patients had more advanced pubertal staging, higher height SDS, and greater pituitary height, while pituitary volume was similar. Global intracranial and total brain volumes did not differ. The WM/ICV fraction was modestly lower in CPP, whereas GM/ICV and CSF/ICV fractions were comparable. No regional brain volumes remained significant after FDR correction. In the stimulation-test subgroup, higher peak LH correlated with smaller total-brain/ICV and cerebrum/ICV fractions and with greater CSF/ICV.
conclusionsAfter adjusting for age and intracranial volume, CPP showed preserved global and regional brain structure. Modest WM reduction and LH-related shifts in brain-CSF distribution suggest subtle hormonally mediated differences in maturational timing. This study provides the largest ICV-normalized volumetric MRI dataset in CPP.
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