Evidence map›Paper›PMID 41845925›Full record

ArticleImmunity, inflammation and disease2026

Mitochondrial Abnormalities of T Lymphocytes in Patients With Maintenance Hemodialysis.

Chunlei Luo, Sizeng Bao, Xueyan Bian, Lingling Bao, Chunyang Ji, Jianwei Ma, Jiancheng Huang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Chunlei LuoDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Sizeng BaoDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Xueyan BianDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.ORCID https://orcid.org/0009-0007-2043-0242
Lingling BaoDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Chunyang JiDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Jianwei MaDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Jiancheng HuangDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

Funding

Key Research and Development Program of Ningbo 2023Z177Medical Science and Technology Project of Zhejiang Province 2020KY819Medical Science and Technology Project of Zhejiang Province 2022KY1105
6 · The paper itself

Abstract

objectiveTo investigate the characteristics of T lymphocyte subsets and mitochondrial function in hemodialysis patients and to explore the effect of hemodialysis on these parameters.

methodsPatients with end-stage renal disease (ESRD) from July 2023 to June 2024, who underwent mitochondrial function detection of T lymphocyte subsets, were included in this retrospective study. Patients were categorized into a hemodialysis group and a pre-dialysis group based on whether they received hemodialysis. The hemodialysis group was further divided into those with dialysis duration ≤ 12 months and those with > 12 months. Peripheral blood from ESRD patients was analyzed by flow cytometry to obtain data on T lymphocyte subsets, mitochondrial mass (MM), and low mitochondrial membrane potential (MMP-Low). Differences in T lymphocyte subsets mitochondrial parameters among distinct groups were analyzed, and the association between hemodialysis and the aforementioned mitochondrial parameters was investigated using multiple linear regression analysis.

resultsA total of 250 patients were enrolled (153 hemodialysis and 97 pre-dialysis). Compared with the pre-dialysis group, the hemodialysis group had significantly lower white blood cell count (5.62 ± 1.63 vs. 6.49 ± 1.93 × 10

conclusionT lymphocyte MM and MMP-Low% differ significantly between hemodialysis and pre-dialysis ESRD patients, and hemodialysis patients exhibit more pronounced T lymphocyte mitochondrial dysfunction.

Indexed as

Kidney Failure, ChronicMitochondriaRenal DialysisT-Lymphocyte SubsetsAgedFemaleHumansLeukocyte CountMaleMembrane Potential, MitochondrialMiddle AgedRetrospective Studies

Identifiers

PMID41845925
PMCPMC13097448

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