Evidence map›Paper›PMID 41845574›Full record

ArticleOral diseases2026

Clinicopathological and Prognostic Features of Pleomorphic Adenoma, Recurrent Pleomorphic Adenoma, and Carcinoma ex Pleomorphic Adenoma: A 20-Year Retrospective Analysis.

Talita de Carvalho Kimura, Luccas Lavareze, Reydson Alcides de Lima-Souza, Nívia Castro Binda, Carlos Takahiro Chone, Alfio José Tincani, Albina Altemani, Fernanda Viviane Mariano

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In one paragraph

Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Talita de Carvalho KimuraDepartment of Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0001-8406-7947
Luccas LavarezeDepartment of Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0003-3464-8879
Reydson Alcides de Lima-SouzaDepartment of Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0001-5045-6960
Nívia Castro BindaDepartment of Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0002-0409-4265
Carlos Takahiro ChoneDepartment of Ophthalmology and Otorhinolaryngology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0002-4217-4629
Alfio José TincaniDepartment of Surgery, Head and Neck Surgery, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0001-6193-2686
Albina AltemaniDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.
Fernanda Viviane MarianoDepartment of Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0003-3694-5025

Funding

São Paulo Research Foundation (FAPESP) 20/08431-4São Paulo Research Foundation (FAPESP) 22/11861-6São Paulo Research Foundation (FAPESP) 23/13091-6São Paulo Research Foundation (FAPESP) 24/05212-0São Paulo Research Foundation (FAPESP) 24/14439-9
6 · The paper itself

Abstract

backgroundPleomorphic adenoma (PA) is the most common salivary gland tumor, and a subset may recur as recurrent PA (RPA) or progress to carcinoma ex pleomorphic adenoma (CXPA). However, comparative evaluations of their biological behavior and prognostic factors remain limited.

objectiveTo characterize and compare the clinical features, pathological patterns, treatment outcomes, and prognostic factors of PA, RPA, and CXPA over a 20-year period at a Brazilian tertiary referral center. MATERIALS AND

methodsA retrospective review of 234 cases (148 PA, 23 RPA, 63 CXPA) diagnosed between 2004 and 2024. Analyses included Fisher's exact test and chi-square test for group comparisons and Cox proportional hazards models for overall (OS) and disease-specific survival (DSS).

resultsPA and RPA mainly affected younger females and presented smaller tumors and shorter clinical evolution than CXPA (p < 0.01). In CXPA, perineural invasion, angiolymphatic invasion, necrosis, recurrence, symptomatology, distant metastasis, and capsular invasion pattern were associated with reduced OS and DSS (p < 0.05).

conclusionThis retrospective study demonstrates distinct clinical and pathological profiles across PA, RPA, and CXPA. In CXPA, clinical and histological factors strongly predict survival and should guide risk stratification, therapeutic decisions, and follow-up strategies.

Indexed as

Adenoma, PleomorphicCarcinomaNeoplasm Recurrence, LocalSalivary Gland NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedPrognosisRetrospective Studiescarcinoma ex pleomorphic adenomahistopathologypleomorphic adenomaprognostic factorsrecurrent pleomorphic adenomasalivary gland tumorssurvival analysis

Identifiers

PMID41845574
PMCPMC13590895

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.