Evidence map›Paper›PMID 41845533›Full record

ArticleAnimal microbiome2026

Maternal supplementation with Lactobacillus reuteri enhances colostrum sIgA secretion and immune function of offspring.

Qian Xie, Pengyi Tian, Qing Duanmu, Mei Yang, Chen Zhang, Jing Wang, Bi E Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qian XieHunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, P. R. China.
Pengyi TianHunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, P. R. China.
Qing DuanmuHunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, P. R. China.
Mei YangHunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, P. R. China.
Chen ZhangAnhui Academy of Agricultural Science, Hefei, 230001, P. R. China.
Jing WangHunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, P. R. China. jingwang023@hunau.edu.cn.
Bi E TanHunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, P. R. China. bietan@hunau.edu.cn.

Funding

Natural Science Foundation of Hunan Province 2024JJ1004, 2022JJ20027
6 · The paper itself

Abstract

Specific maternal gut microbiota can activate immune responses in the gut-associated lymphoid tissues, driving the secretion of maternal immunoglobulins into the milk and facilitating the passive immunity of the offspring via the entero-mammary axis. This study aims to investigate the distinct gut microbiota profiles between large white (LW) sows and Ningxiang (NX) sows, and to explore probiotic for maternal and offspring intestinal health. Lactobacillus reuteri (LR) was significantly enriched in the feces of NX sows and positively correlated with colostral immunoglobulin (Ig) levels, specifically IgG (r = 0.568, P = 0.014), IgA (r = 0.573, P = 0.013), and IgM (r = 0.721, P = 0.0007). Maternal supplementation with LR isolated from NX pigs enhanced mammary IgA production and elevated secretory IgA (sIgA) levels in both colostrum and the ileum of mice. Importantly, maternal dietary LR supplementation improved immune functions of offspring mice challenged with enterotoxigenic escherichia coli (ETEC), as evidenced by reduced systemic inflammation (TNF-α, IFN-γ) and preserved intestinal barrier function. These results support the potential of NX pig-derived LR as a probiotic to improve the health of maternal and offspring via the gut-mammary axis.

Indexed as

ImmunoglobulinsIntestinal microbiotaLactobacillus reuteriNingxiang pigOffspring development

Identifiers

PMID41845533
PMCPMC13107913

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.