Evidence map›Paper›PMID 41845528›Full record

ReviewInternational journal of dermatology2026

CARD14-Associated Papulosquamous Eruption (CAPE): An Updated Review of Pathogenesis and Treatment.

Katherine Gavagan, Aria Trager, Negar Esfandiari, Darius Mehregan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Editors Highlights-October 2026.International journal of dermatology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katherine GavaganDepartment of Dermatology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Aria TragerMichigan State University College of Osteopathic Medicine, East Lansing, Michigan, USA.ORCID https://orcid.org/0009-0001-6739-9701
Negar EsfandiariDepartment of Dermatology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Darius MehreganDepartment of Dermatology, Wayne State University School of Medicine, Detroit, Michigan, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CARD14-associated papulosquamous eruption (CAPE) is a rare genetically mediated inflammatory skin disorder caused by gain-of-function variants in the CARD14 gene. It typically presents in infancy or early childhood with clinical features resembling both psoriasis and pityriasis rubra pilaris, and often exhibits a poor response to conventional therapies. An increasing number of studies support favorable outcomes with biologic medications, particularly interleukin (IL)-12/23 and IL-17 inhibitors, for the treatment of CAPE. This literature review summarizes the etiology and pathophysiology of CAPE, with a focus on clinical features, genetic findings, and developments in treatment strategies.

Indexed as

CARD Signaling Adaptor ProteinsGuanylate CyclaseMembrane ProteinsSkin Diseases, PapulosquamousBiological ProductsHumansBiological ProductsCARD14 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseMembrane ProteinsbiologicsCAPECARD14‐associated papulosquamous eruptiontreatment

Identifiers

PMID41845528
PMCPMC13569229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.