Evidence map›Paper›PMID 41845501›Full record

ReviewJournal of animal science and biotechnology2026

Mitochondrial dysfunction in the bovine mammary gland: regulatory mechanisms and therapeutic strategies.

Taiyu Shen, Ming Li, Xudong Sun, Zhaoju Deng, Hailey Pitts, Derek Nolan, Juan J Loor, Chuang Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Taiyu Shen *National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Ming Li *National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Xudong SunHeilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, No. 5 Xinyang Road, Daqing, Heilongjiang Province, 163319, China.
Zhaoju DengNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Hailey PittsDepartment of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, 61801, USA.
Derek NolanDepartment of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, 61801, USA.
Juan J LoorDepartment of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, 61801, USA.
Chuang XuNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. xuchuang@cau.edu.cn.

Funding

China Agriculture Research System CARS-36the Joint Funds of the National U24A20453the National Natural Science Foundation of China 32125038the National Natural Science Foundation of China 32302936
6 · The paper itself

Abstract

Periparturient metabolic stress or pathogen infections leading to inflammation reduce milk yield and cause mammary dysfunction, thus, causing severe economic losses to dairy farming. As the primary organelle for cellular energy production, calcium regulation, cell death, and metabolism, mitochondrial homeostasis plays a crucial role in maintaining normal mammary gland function. This review focuses on the regulatory mechanisms of mitochondrial homeostasis and the effect of mitochondrial dysfunction on homeostatic mechanisms in bovine mammary gland. Furthermore, we summarize several potential therapeutic strategies targeting mitochondrial metabolic dysfunction to alleviate mammary tissue damage.

Indexed as

ApoptosisBovineInnate immunityMammary gland homeostasisReactive oxygen species

Identifiers

PMID41845501
PMCPMC12998065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.