Evidence map›Paper›PMID 41845500›Full record

ArticleJournal of intensive care2026

Short- and long-term outcomes of elderly patients with acute kidney injury to acute kidney disease.

Qinglin Li, Dong Zhang, Xiaonan Ding, Qiang Lyu, Hanyu Zhu, Qiangguo Ao, Xiangmei Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qinglin Li *Senior Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-Vascular Diseases, Beijing, 100853, China.
Dong Zhang *Senior Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-Vascular Diseases, Beijing, 100853, China.
Xiaonan DingSenior Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-Vascular Diseases, Beijing, 100853, China.
Qiang LyuSenior Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-Vascular Diseases, Beijing, 100853, China.
Hanyu ZhuSenior Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-Vascular Diseases, Beijing, 100853, China.
Qiangguo Ao *Department of Geriatric Nephrology, The Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100053, China. aoqg301@126.com.
Xiangmei Chen *Senior Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-Vascular Diseases, Beijing, 100853, China. xmchen301301@126.com.

Funding

National Key Research and Development Program of China 2023YFC3605500, 2023YFC3605501
6 · The paper itself

Abstract

objectiveAcute kidney disease (AKD) describes acute or subacute renal damage and/or loss of kidney function between 7 and 90 days after AKI initiation. Because there are few reports on AKD in older patients, the present study evaluated the risk factors and outcomes of AKD in older patients.

methodsA retrospective, observational, multicenter cohort study was conducted on consecutive patients (≥ 75 years) admitted to Chinese PLA General Hospital between 2007 and 2022. AKI was diagnosed on the basis of the Kidney Disease: Improving Global Outcomes (KDIGO) SCr-based criteria. AKD was defined as AKI (KDIGO stage 1 or greater) that persisted for 7 days or longer. The outcomes included short- and long-term mortality and proportion of de novo chronic kidney disease (CKD).

resultsIn total, 1395 elderly patients were included in the analysis, including 1245 (89.2%) patients who had de novo kidney injury (DNKI). Among those who had DNKI, 760 (61.0%) patients met the AKD criteria. Overall, 1121 (90.0%) patients were male, and the median age was 88 (IQR = 84 - 91). A lower baseline estimated glomerular filtration rate, higher sodium level, higher magnesium level, hypoalbuminemia, anemia, mechanical ventilation, renal replacement therapy, and increased AKI severity were associated with the development of AKD. Compared with early AKI recovery, progression to AKD was associated with increased 28-day mortality (time ratio [TR] = 0.427, 95% CI 0.298-0.599; P < 0.001), 90-day mortality (TR = 0.427, 95% CI 0.309-0.590; P < 0.001), 1-year mortality (TR = 0.499, 95% CI 0.394-0.631; P < 0.001) and de novo CKD (OR = 4.085, 95% CI 2.834-5.889; P < 0.001).

conclusionsThese findings highlight the importance of early AKI recognition and management to prevent the progression of AKI to AKD and long-term adverse outcomes.

Indexed as

Acute kidney diseaseAcute kidney injuryChronic kidney diseaseRecoveryRisk factors

Identifiers

PMID41845500
PMCPMC13112905

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.