ArticleBMC research notes2026
Histological effects of intra-articular allogeneic leukocyte-rich and leukocyte-poor platelet-rich plasma in healthy rabbit knees: an exploratory study.
Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
objectivePlatelet-rich plasma (PRP) is used to treat knee osteoarthritis and cartilage injuries, but its effects on healthy joint tissues are unclear. This exploratory study compared histological responses to allogeneic leukocyte-rich (LR) and leukocyte-poor (LP) PRP versus saline in healthy rabbit knees.
resultsEighteen knees from nine healthy male Japanese white rabbits received a single intra-articular injection of saline, LR-PRP (Vets), or LP-PRP (Cellaid) (n = 6 knees/group). At 4 weeks, trochlear cartilage and suprapatellar pouch synovium were evaluated by hematoxylin-eosin histology. Chondrocyte nuclei were counted in a predefined cartilage region (0.538 cm²) and synovitis scored using the OARSI rabbit system (0-11). PRP composition was not quantitatively characterized; LR/LP labels were kit-based. Mean chondrocyte counts were 345 ± 100, 365 ± 70, and 394 ± 23 nuclei/0.538 cm², and mean synovial lesion scores were 2.67 ± 1.21, 2.50 ± 1.52, and 2.17 ± 0.41 in the saline, LR-PRP, and LP-PRP groups, respectively. In mixed-effects models accounting for within-rabbit correlation, no contrast remained statistically significant after Holm adjustment. Mild synovial changes were observed in all groups.
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