Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Inadvertent parathyroidectomy in thyroid surgery with and without near-infrared autofluorescence: a two-centre retrospective observational study.
Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInadvertent parathyroidectomy is a recognised complication of thyroid surgery and contributes to post-operative hypoparathyroidism. Adjuncts such as near-infrared autofluorescence imaging may aid parathyroid identification, but multi-centre evidence remains limited. This study evaluated rates of inadvertent parathyroidectomy in thyroid surgery performed with and without autofluorescence, and examined the impact of central neck dissection, participation in a fluorescence-guided surgery trial, and temporal changes in practice.
methodsThis two-centre retrospective cohort study included adults undergoing hemithyroidectomy, total thyroidectomy, or completion thyroidectomy from 2021 to 2023. The primary outcome was inadvertent parathyroidectomy confirmed on histopathology. Key exposures were participation in a fluorescence-guided surgery trial and intraoperative near-infrared autofluorescence use. Prespecified subgroups were total/completion procedures and operations with or without central neck dissection.
resultsA total of 829 operations were included. Inadvertent parathyroidectomy occurred in 18.5% overall. Rates were higher with central neck dissection than without (41.1% vs. 15.7%; p < 0.001). NIFTy trial participation showed no significant effect (17.4% vs. 18.7%; p = 0.816). Autofluorescence imaging was associated with lower rates overall (14.0% vs. 20.3%; p = 0.042), though the reduction was not statistically significant in the total/completion subgroup (15.1% vs. 23.6%; p = 0.053). Rates declined from 21.6% in 2021 to 13.9% in 2023 (p = 0.022).
conclusionsInadvertent parathyroidectomy remains common, particularly when central neck dissection is performed. Near-infrared autofluorescence may offer modest benefit, while temporal improvements likely reflect increased surgical and pathological awareness, routine specimen examination, and more consistent reporting practices.
Indexed as
Identifiers
41845116What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.