ArticleFunctional & integrative genomics2026
Transcriptome profiling of Rehmannia glutinosa uncovers ABA/GA antagonism mechanisms in tuberous root initiation.
Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rehmannia glutinosa tuberous roots are the critical determinant of its medicinal and economic values. The swelling of adventitious roots is a prerequisite for tuberous root initiation, which is antagonistically regulated by abscisic acid (ABA) and gibberellins (GA). However, the underlying mechanisms of ABA/GA antagonism in this context remain poorly understood. In this study, exogenous ABA significantly promoted adventitious root swelling, whereas GA exerted an inhibitory effect. To investigate the potential mechanisms, transcriptome analysis was performed on R. glutinosa roots treated with ABA or GA. Compared with control samples, 7,416 and 9,034 differentially expressed genes (DEGs) were identified in ABA-treated and GA-treated roots, respectively. Expression pattern analysis of DEGs involved in ABA and GA metabolism and signal transduction, combined with dynamic hormone measurements, revealed the dynamic regulation of ABA/GA equilibrium. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene set enrichment analysis (GSEA) demonstrated that starch accumulation and cell wall biosynthesis and modification were closely associated with adventitious root swelling. Weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network analysis identified DREBs, ERFs, and PERs as key regulators in ABA/GA antagonism. Transient expression of RgERF017 and RgPER10 in tobacco altered the expression of ABA/GA metabolic genes. This study provides a comprehensive analysis of the antagonistic regulatory network between ABA and GA during R. glutinosa tuberous root initiation, deepening our understanding of the molecular mechanisms underlying tuberous root formation.
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