Evidence map›Paper›PMID 41845066›Full record

ArticleBasic research in cardiology2026

Short-term blockade of E-prostanoid 3 receptor mitigates necroinflammation and ameliorates ischemia/reperfusion- and doxorubicin-induced acute myocardial injury.

Dong He, Yequn Chen, Jiahui Ge, Jinwei Guo, Zhen Wang, Gang Yu, Shiwan Wu, Jing Leng, Bin Wang, Shunyu Pang and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Basic research in cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Dong He *Cardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Yequn Chen *Department of Cardiology, First Affiliated Hospital and Cardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Jiahui GeCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Jinwei GuoCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Zhen WangCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Gang YuCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Shiwan WuDepartment of Cardiology, First Affiliated Hospital and Cardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Jing LengSchool of Basic Medical Sciences, Shenyang Medical College, Shenyang, People's Republic of China.
Bin WangCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Shunyu PangCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Xijian ChenCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Yineng XuCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Cheng PengCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Jianye YangCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Shijun LiuCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Anhong CaiCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Zhengpeng ZengCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Xinya ShiCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Siyi LingCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Yukuan ChenCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China.
Yingbi ZhouCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China. yz_sumc@163.com.
Bin LiuCardiovascular Research Center, Shantou University Medical College, 22 Xin-Ling Rd, Shantou, 515041, People's Republic of China. bliu@stu.edu.cn.ORCID 0000-0001-5177-3132

Funding

National Natural Science Foundation of China 82070506National Natural Science Foundation of China 82270466Priority-Field Research Program for Universities of Guangdong Universities 2024ZDZX2026the Innovative Team Research Program for Universities of Guangdong Province 2022KCXTD009
6 · The paper itself

Abstract

E-prostanoid 3 receptor (EP3) plays an important role in maintaining normal heart growth and development, and its activation may drive acute inflammation and influence intracellular Ca

Indexed as

DoxorubicinMyocardial Reperfusion InjuryMyocytes, CardiacReceptors, Prostaglandin E, EP3 SubtypeAnimalsDisease Models, AnimalHumansInflammationMaleMiceMice, Inbred C57BLMice, KnockoutMyocardiumNecrosisDoxorubicinPtger3 protein, mouseReceptors, Prostaglandin E, EP3 SubtypeAcute myocardial injuryCalcium overloadInflammationProstaglandinRegulated necrosis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.