Evidence map›Paper›PMID 41845050›Full record

ArticleNature cell biology2026

Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions.

Shan He, Linnea M Lemma, Alejandro Martinez-Calvo, Guanhua He, Jessica H Hennacy, Lianyong Wang, Sabrina L Ergun, Ashwani K Rai, Colton Wang, Luke Bunday and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. The exchange dynamics of client molecules in biomolecular condensates.bioRxiv : the preprint server for biology · 2026
    Article
  4. RBMP2 shapes specialized membranes for CObioRxiv : the preprint server for biology · 2026
    Article
  5. Regulatory logic of theFrontiers in plant science · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Shan He *Department of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0003-2958-9659
Linnea M Lemma *Howard Hughes Medical Institute, Princeton University, Princeton, NJ, USA.
Alejandro Martinez-CalvoPrinceton Center for Theoretical Science, Princeton University, Princeton, NJ, USA.
Guanhua HeDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Jessica H HennacyDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Lianyong WangDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Sabrina L ErgunDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Ashwani K RaiDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Colton WangDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Luke BundayDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Angelo Kayser-BrowneDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Quan WangLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Clifford P BrangwynneHoward Hughes Medical Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-1350-9960
Ned S WingreenDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA. wingreen@princeton.edu.ORCID http://orcid.org/0000-0001-7384-2821
Martin C JonikasDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA. mjonikas@princeton.edu.ORCID http://orcid.org/0000-0002-9519-6055

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Learning principles from the pyrenoid, a phase-separated organelleR01GM140032 · NIGMS · PRINCETON UNIVERSITY · PI JONIKAS, MARTIN CASIMIR, WINGREEN, NED S · 2021 to 2024
$2.0M
National Science Foundation (NSF) MCB-1914989National Science Foundation (NSF) MCB-2410354NIGMS NIH HHS R01 GM140032NIGMS NIH HHS T32 GM007388U.S. Department of Energy (DOE) DE-SC0020195U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R01GM140032-01
6 · The paper itself

Abstract

Biomolecular condensates spatially organize cellular functions, but the regulation of their size, number, dissolution and re-condensation is poorly understood. The pyrenoid, an algal biomolecular condensate that mediates one-third of global CO

Indexed as

Biomolecular CondensatesCell CycleChlamydomonas reinhardtiiChloroplastsPlant ProteinsMutationPhase SeparationPhosphorylationRibulose-Bisphosphate CarboxylasePlant ProteinsRibulose-Bisphosphate Carboxylase

Identifiers

PMID41845050
PMCPMC13086578

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.