Evidence map›Paper›PMID 41845010›Full record

ArticleCommunications biology2026

Ocean acidification disrupts the biomineralization process in the oyster Crassostrea virginica via intracellular calcium signaling dysregulation.

Chi Huang, Joseph Matt, Christopher Hollenbeck, Leisha Martin, Wei Xu

Abstract read
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chi HuangDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine & Biomedical Science, Texas A&M University, College Station, TX, USA.
Joseph MattDepartment of Life Sciences, College of Science, Texas A&M University - Corpus Christi, Corpus Christi, TX, USA.
Christopher HollenbeckDepartment of Life Sciences, College of Science, Texas A&M University - Corpus Christi, Corpus Christi, TX, USA.
Leisha MartinDepartment of Life Sciences, College of Science, Texas A&M University - Corpus Christi, Corpus Christi, TX, USA.
Wei XuDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine & Biomedical Science, Texas A&M University, College Station, TX, USA. wxu1@tamu.edu.ORCID http://orcid.org/0000-0003-0023-4045

Funding

NSF | BIO | Division of Integrative Organismal Systems (IOS) 1903719NSF | BIO | Division of Integrative Organismal Systems (IOS) 2046049
6 · The paper itself

Abstract

Calcium is a key component in the shell and skeleton structure, serving as a second messenger for regulating biomineralization across many species. Ocean acidification (OA) is well-studied for causing shell dissolution in marine bivalve species by disordering calcium deposition. However, the regulatory pathway of calcification affected by OA remains unclear. This study assessed eastern oyster (Crassostrea virginica) to determine how calcium signaling responds to elevated pCO

Indexed as

BiomineralizationCalcification, PhysiologicCalcium SignalingCrassostreaOcean AcidificationAnimalsAnimal ShellsCalciumCalmodulinCarbon DioxideHydrogen-Ion ConcentrationCalciumCalmodulinCarbon Dioxide

Identifiers

PMID41845010
PMCPMC13144384

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.