Evidence map›Paper›PMID 41844991›Full record

ArticleScientific reports2026

The FOXE1 rs965513 polymorphism: a pleiotropic risk locus associated with thyroid function, BRAF

Wenran Zhang, Yu Gao, Simei Zeng, Jingmin Li, Shuhua Wang, Yaming Huang, Jiaqing Dou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenran ZhangDepartment of Endocrinology, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Juchao District, Hefei, Anhui, China.
Yu GaoDepartment of Endocrinology, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Juchao District, Hefei, Anhui, China.
Simei ZengDepartment of Endocrinology, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Juchao District, Hefei, Anhui, China.
Jingmin LiDepartment of Endocrinology, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Juchao District, Hefei, Anhui, China.
Shuhua WangDepartment of Endocrinology, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Juchao District, Hefei, Anhui, China.
Yaming HuangDepartment of Endocrinology, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Juchao District, Hefei, Anhui, China.
Jiaqing DouDepartment of Endocrinology, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Juchao District, Hefei, Anhui, China. djqch2@163.com.

Funding

the Colleges and Universities of Anhui Provincial Department of Education No. KJ2021ZD0033
6 · The paper itself

Abstract

Although papillary thyroid cancer (PTC) genetic research has advanced from identifying driver genes to investigating susceptibility loci and gene-environment interactions, data in Chinese populations remain limited. A case-control study was conducted, enrolling 75 patients with PTC and 271 patients with benign thyroid nodules. After testing for Hardy-Weinberg equilibrium, the associations of the single nucleotide polymorphism (SNP) at the rs965513 locus with genetic susceptibility to PTC, risk of BRAF

Indexed as

Forkhead Transcription FactorsGenetic Predisposition to DiseaseMutationPolymorphism, Single NucleotideProto-Oncogene Proteins B-rafThyroid Cancer, PapillaryThyroid GlandThyroid NeoplasmsAdultAllelesCase-Control StudiesFemaleGenotypeHumansMaleMiddle AgedBRAF protein, humanForkhead Transcription FactorsFOXE1 protein, humanProto-Oncogene Proteins B-rafBRAF V600EMultiple genetic modelsPapillary thyroid cancerPolymorphismSusceptibilityTSH

Identifiers

PMID41844991
PMCPMC13133175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.