Evidence map›Paper›PMID 41844958›Full record

ReviewCancer metastasis reviews2026

Neuro-tumor interactions in peripheral tumors.

Xueshiyu Ma, Peixuan Ji, Jiahao Zheng, Shuqi Cai, Kan Xu, Yongwei Sun, Dejun Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer metastasis reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xueshiyu Ma *State Key Laboratory of Systems Medicine for Cancer, Department of Biliary-Pancreatic Surgery, School of Medicine, Shanghai Cancer Institute, Ren Ji Hospital, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China.
Peixuan Ji *Division of Gastroenterology and Hepatology, NHC Key Laboratory of Digestive Diseases; NHC Key Laboratory of Digestive Diseases, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiao Tong University, Shanghai, 200001, China.
Jiahao Zheng *State Key Laboratory of Systems Medicine for Cancer, Department of Biliary-Pancreatic Surgery, School of Medicine, Shanghai Cancer Institute, Ren Ji Hospital, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China.
Shuqi CaiState Key Laboratory of Systems Medicine for Cancer, School of Medicine, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Kan XuState Key Laboratory of Systems Medicine for Cancer, Department of Biliary-Pancreatic Surgery, School of Medicine, Shanghai Cancer Institute, Ren Ji Hospital, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China.
Yongwei SunState Key Laboratory of Systems Medicine for Cancer, Department of Biliary-Pancreatic Surgery, School of Medicine, Shanghai Cancer Institute, Ren Ji Hospital, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China. syw0616@126.com.
Dejun LiuState Key Laboratory of Systems Medicine for Cancer, Department of Biliary-Pancreatic Surgery, School of Medicine, Shanghai Cancer Institute, Ren Ji Hospital, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China. liudejun@renji.com.

Funding

Natural Science Foundation of China 82472917
6 · The paper itself

Abstract

The nervous system is now recognized as a pivotal regulator of cancer, marking a paradigm shift that recasts nerves from passive bystanders to active drivers within the tumor microenvironment (TME). This review defines the "neural niche," differentiating passive perineural invasion (PNI) from active tumor innervation. We examine how sympathetic signaling drives an "angio-metabolic switch" and immune evasion, whereas parasympathetic inputs exert context-dependent control over stemness and inflammation. We also highlight the underappreciated role of sensory neurons in promoting T-cell exhaustion via neuropeptides like calcitonin gene-related peptide (CGRP). Finally, we assess therapeutic strategies targeting neural dependence-from repurposing β-blockers to deploying nanotechnologies. Targeting neuro-tumor crosstalk offers a promising strategy to overcome therapeutic resistance and restore anti-tumor immunity.

Indexed as

NeoplasmsNeurogenesisPeripheral Nervous SystemTumor MicroenvironmentAnimalsCancer-Associated FibroblastsHumansImmunotherapyNeovascularization, PathologicNerve dependenceNeural invasionNeuroscienceNeurotransmitter antagonists and tumor innervation

Identifiers

PMID41844958

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.