Evidence map›Paper›PMID 41844938›Full record

ArticleMikrochimica acta2026

A quenched electrochemiluminescence immunosensor based on luminol-Au NPs/Co-Fe-MOF and CuO@UiO-66-NH

Xinyi Yu, Yuzhu Dai, Jun Cheng, Zhu Wang, Haoyuan Wu, Tingting Ye, Yumei Ge, Weizhong Wang, Zhen Guo

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinyi YuDepartment of Clinical Laboratory, The 903rd Hospital of the Joint Logistic Support Force, Hangzhou, 310013, China.
Yuzhu Dai *Department of Clinical Laboratory, The 903rd Hospital of the Joint Logistic Support Force, Hangzhou, 310013, China.
Jun Cheng *Department of Clinical Laboratory, The 903rd Hospital of the Joint Logistic Support Force, Hangzhou, 310013, China.
Zhu WangSchool of Public Health, Hangzhou Medical College, Hangzhou, 310014, China.
Haoyuan WuSchool of Public Health, Hangzhou Medical College, Hangzhou, 310014, China.
Tingting YeEmergency and Critical Care Center, Department of Emergency Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.
Yumei GeLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, China. 11218070@zju.edu.cn.
Weizhong WangLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, China.
Zhen GuoDepartment of Clinical Laboratory, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Funding

Zhejiang Provincial Health Bureau 2023RC173Zhejiang Provincial Natural Science Foundation LBY24H200002
6 · The paper itself

Abstract

An innovative and highly sensitive quenching-type electrochemiluminescence (ECL) immunosensor for the detection of hemagglutinin, a key surface protein of the influenza A (H1N1) virus, is presented. For the first time, a composite of cobalt-iron bimetallic organic framework loaded with gold nanoparticles (Au NPs/Co-Fe-MOF), exhibiting high peroxidase-like activity and capable of significantly enhancing the initial ECL signal in a H2O2 system, is combined with a composite of zirconium-based metal-organic framework loaded with copper oxide nanoparticles (CuO@UiO-66-NH2). The high overlap between the ultraviolet absorption spectrum of CuO@UiO-66-NH2 and the emission spectrum of luminol allows for a substantial reduction in the initial signal via ECL resonance energy transfer. Under optimized conditions, the sensor exhibited a linear range from 0.001 to 80 ng mL⁻1, with a detection limit of 0.00047 ng mL⁻1. Moreover, no significant cross-reactivity with related viruses was observed, demonstrating excellent specificity and good stability. This easy-to-operate method is expected to offer a new approach with strong application potential for detecting H1N1 influenza virus.

Indexed as

Electrochemical TechniquesHemagglutinin Glycoproteins, Influenza VirusInfluenza A Virus, H1N1 SubtypeMetal NanoparticlesMetal-Organic FrameworksAntibodies, ImmobilizedBiosensing TechniquesCobaltCopperGoldHumansImmunoassayLimit of DetectionLuminescent MeasurementsLuminolPhthalic AcidsAntibodies, ImmobilizedCobaltCopperGoldHemagglutinin Glycoproteins, Influenza VirusLuminolMetal-Organic FrameworksPhthalic AcidsUiO-66Au NPs/Co-Fe-MOFCuO@UiO-66-NH2Electrochemiluminescence resonance energy transferInfluenza ALuminolModified glassy carbon electrode

Identifiers

PMID41844938

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.