Evidence map›Paper›PMID 41844899›Full record

ArticleCell death and differentiation2026

Hepatic GAPDH prevents excessive fasting-induced steatosis via serine-dependent inhibition of diacylglycerol synthesis.

Yihao Zhou, Yan Yuan, Yunhao Xie, Jiajian Shi, Hejun Song, Yuxia Liu, Jiao Wang, Pei Fan, Tongcan Cui, Hong Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yihao ZhouState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Center for Life and Medical Sciences; Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0009-0008-9711-3007
Yan YuanState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Center for Life and Medical Sciences; Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, China.
Yunhao XieState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Center for Life and Medical Sciences; Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, China.
Jiajian ShiSchool of Pharmacy, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.ORCID 0009-0007-9329-0674
Hejun SongState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Center for Life and Medical Sciences; Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, China.
Yuxia LiuState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Center for Life and Medical Sciences; Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, China.
Jiao WangWuhan No.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Pei FanMass Spectrometry Platform, College of Life Sciences, Wuhan University, Wuhan, China.
Tongcan CuiSchool of Pharmacy, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Hong ChenSchool of Pharmacy, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0003-3478-6139
Xiaolu ZhaoState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Center for Life and Medical Sciences; Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, China.
Xinran LiuSchool of Pharmacy, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Kun HuangSchool of Pharmacy, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China. kunhuang@hust.edu.cn.ORCID 0000-0002-0808-2325
Ling ZhengState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Center for Life and Medical Sciences; Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, China. lzheng@whu.edu.cn.ORCID 0000-0002-6545-4180

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fasting-induced metabolic remodeling is a fundamental process maintaining systemic homeostasis, with profound implications for metabolic disease interventions. During fasting, liver establishes a regulatory network centered on gluconeogenesis that integrates major fuels to keep physiological energy homeostasis. Here, we report that GAPDH, a key enzyme in both glycolysis and gluconeogenesis, senses fasting stress in the liver. Compared to wildtype controls, hepatocyte Gapdh deficiency (Gap

Indexed as

DiglyceridesFastingFatty LiverGlyceraldehyde-3-Phosphate DehydrogenasesLiverSerineAnimalsHepatocytesMaleMiceMice, Inbred C57BLPhosphatidate PhosphataseDiglyceridesGlyceraldehyde-3-Phosphate DehydrogenasesLpin1 protein, mousePhosphatidate PhosphataseSerine

Identifiers

PMID41844899
PMCPMC13631230

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.