Evidence map›Paper›PMID 41844844›Full record

ArticleThe EMBO journal2026

Dual ubiquitin signalling by SLOMO controls AUX1 activity and turnover during root gravitropism.

Lixia Pan, Shanshuo Zhu, Shao-Li Yang, Nathan Mellor, Francesca R Iacobini, Tingyu Zhu, Pia Neyt, Brigitte van de Cotte, Michaël Vandorpe, Ranjan Swarup and 5 more

Abstract read
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In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Lixia Pan *Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Shanshuo Zhu *Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0003-4828-5378
Shao-Li YangDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0003-0989-5448
Nathan MellorDivision of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Nottingham, UK.
Francesca R IacobiniDepartment of Biology, University of Fribourg, Fribourg, Switzerland.
Tingyu ZhuDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-2194-6386
Pia NeytDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Brigitte van de CotteDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Michaël VandorpeDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Ranjan SwarupDivision of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Nottingham, UK.
Daniël Van DammeDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Markus M GeislerDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0002-6641-5810
Kris GevaertVIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.
Leah R BandDivision of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Nottingham, UK.
Ive De SmetDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium. ive.desmet@psb.vib-ugent.be.ORCID http://orcid.org/0000-0003-4607-8893

Funding

Chinese Scholarship Council 201806870020Chinese Scholarship Council 202208410058Chinese Scholarshop Council 201506230173Ghent University Special Research Fund 01CD0523Swiss National Funds 310030_197563UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/M019837/1
6 · The paper itself

Abstract

Gravity-directed growth ensures that shoots and roots grow upwards and downwards, respectively. To achieve this, the organ's angle with respect to gravity drives the asymmetric redistribution of the plant hormone auxin and consequently differential elongation, thus creating a curvature of the organ. In addition to efflux transporters, the auxin influx transporter AUXIN RESISTANT 1 (AUX1) is essential for auxin redistribution during root gravitropism. Here, we show that the F-box protein SLOMO regulates AUX1 via two distinct mechanisms. First, SLOMO promotes proteolytic degradation of AUX1, possibly in an indirect manner. Second, SLOMO controls the ubiquitination of K261, K264, and K266, thus potentially affecting AUX1 auxin transport properties that are regulated by these residues. This reveals a dual mode of SLOMO-mediated regulation of AUX1, including a novel, non-proteolytic role for SLOMO-mediated ubiquitination in addition to SLOMO-mediated degradation of AUX1.

Indexed as

ArabidopsisArabidopsis ProteinsF-Box ProteinsGravitropismPlant RootsSignal TransductionUbiquitinGene Expression Regulation, PlantIndoleacetic AcidsProteolysisUbiquitinationArabidopsis ProteinsAUX1 protein, ArabidopsisF-Box ProteinsIndoleacetic AcidsUbiquitinAuxinF-box ProteinGravitropismRootUbiquitination

Identifiers

PMID41844844
PMCPMC13083858

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.