ArticleScientific reports2026
HLA - C*03:02:02 and DPA1*01:03:01 protect against discoid rash in Thai Systemic Lupus Erythematosus patients.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aims to characterized high-resolution HLA alleles in Thai SLE patients and investigate their clinical correlations.The 6 digits HLA allele imputation was conducted using previously published Thai genotyping array data (SLE = 892, healthy controls = 1,638), utilizing population-matched HLA sequencing data as reference (n = 381). The HLA genes (HLA-A, HLA-C, HLA-B, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-DPB1) was imputed independently using HIBAG R package. Case–control analysis, haplotype analyses, and clinical correlations were performed using the BIGDAWG R package. Our imputation replicates previously reported associations in Thai SLE patients and further refines the implicated alleles to 6 digits, including DRB1*15:02:01, DRB1*12:02:01, DQB1*05:01:24 and DQB1*03:01:01. Two novel HLA class II alleles were identified, including DQA1*01:01:01 (Pc = 3.74E-09, OR = 1.83 [1.51–2.22]) and DPA1*02:01:01 (Pc = 1.77E-04, OR = 1.40 [1.19–1.66]). Haplotype analysis revealed that DQA1*01:01:01 ~ DQB1*05:01:24 conferred an increased risk for SLE (Pc = 5.64E-11, OR = 1.98 [1.62–2.42]). Clinical correlation showed haplotype B*58:01:01 ~ C*03:02:02 were protective against discoid rash (Pc < 0.05, OR = 0.47 [0.25–0.83]). This study highlights the utility of microarray data in generating high-resolution HLA alleles and conducting association analyses, which may facilitate the prognosis marker for SLE-related skin manifestations.
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