Evidence map›Paper›PMID 41844693›Full record

ArticleScientific reports2026

Coupling MgSO

Ahmed Abdulhafez Hamad, Mohamed A M Ali, Anis Ahmad Chaudhary, Reem H Obaydo, Safaa F Saleh, Angum M M Ibrahim, Wedad Mawkili, Nujud Maslamani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Sustainable Hybrid (NHLuminescence : the journal of biological and chemical luminescence · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmed Abdulhafez HamadDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.ORCID http://orcid.org/0000-0002-7088-0723
Mohamed A M AliDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia.ORCID http://orcid.org/0000-0001-8217-0262
Anis Ahmad ChaudharyDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia.ORCID http://orcid.org/0000-0002-1506-7836
Reem H ObaydoDepartment of Analytical and Food Chemistry, Faculty of Pharmacy, Ebla Private University, Idlib, Syria. obaydo.reem@ebla.edu.sy.ORCID http://orcid.org/0000-0003-1496-4612
Safaa F SalehPharmaceutical Chemistry and Pharmacognosy Department, College of Pharmacy, Jazan University, 45142, Jazan, Saudi Arabia.ORCID http://orcid.org/0000-0001-8978-4670
Angum M M IbrahimDepartment of Clinical Pharmacy, Al-Rayan National College of Health Sciences, Al-Rayan National Colleges, Al Madinah Al Munawwarah, Saudi Arabia.ORCID http://orcid.org/0000-0003-2210-0769
Wedad MawkiliDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, 45142, Jazan, Saudi Arabia.ORCID http://orcid.org/0009-0005-0710-6048
Nujud MaslamaniDepartment of Physical Sciences, Chemistry Division, College of Science, Jazan University, P.O. Box. 114, Jazan, 45142, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0002-4676-8598

Funding

This work was supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) Grant number IMSIU-DDRSP2601
6 · The paper itself

Abstract

An innovative, sustainable analytical approach was developed by coupling an Epsom salt, E518 (magnesium sulfate)-facilitated salting-out assisted liquid-liquid extraction (SALLE) system with a safe molecular fluorescent probe, Celfia Pink B (CPB), employing a fluorescence turn-off sensing strategy. MgSO₄ acts as a green salting-out agent, enhancing phase separation efficiency and producing cleaner extracts with higher analyte recovery. CPB, a safe, food-grade dye, serves as a selective fluorogenic probe whose emission at 553 nm is quenched upon electrostatic ion-pair complex formation with Cinacalcet HCl under mildly acidic conditions. The method exhibited excellent linearity (0.08-1.3 µg/mL) with high sensitivity (LOD = 0.024 µg/mL; LOQ = 0.075 µg/mL). Validation according to ICH guidelines demonstrated robustness, precision, and accuracy across pharmaceutical formulations and biological matrices. Sustainability assessment using the WAC framework categorized the platform as "white," highlighting low environmental impact, safe operation, and simplicity. By minimizing organic solvent use and eliminating hazardous reagents, this MgSO₄-assisted SALLE/fluorescence turn-off approach provides a green, highly sensitive, and versatile tool for trace-level determination of Cinacalcet HCl in pharmaceutical and biological matrices.

Indexed as

CinacalcetFluorometryLiquid-Liquid ExtractionMagnesium SulfateFluorescent DyesHumansSpectrometry, FluorescenceCinacalcetFluorescent DyesMagnesium SulfateCPB molecular probeEpsom salt-facilitated SALLEFluorescence turn-off sensing strategySustainable chemistry and human Health considerationsTrace-level cinacalcet HCl determination in pharmaceutical and biological matrices

Identifiers

PMID41844693
PMCPMC13129048

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.