Evidence map›Paper›PMID 41844615›Full record

ArticleNature communications2026

IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation.

Cody G Kempen, Ankita Singh, Keith A Breau, Hafiz I Tariq, Yangle Yu, Stephen J Gaudino, Tej Bahadur, Emilia Orzechowska-Licari, Onur Eskiocak, Kiyoshi Shiomitsu and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Cody G KempenDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Ankita SinghDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Keith A BreauDepartment of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hafiz I TariqDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0009-0009-3699-1743
Yangle YuDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0009-0007-7578-1920
Stephen J GaudinoDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Tej BahadurDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Emilia Orzechowska-LicariDepartment of Pediatrics, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Onur EskiocakCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Kiyoshi ShiomitsuDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0009-0000-6427-1721
Richard BlumbergDepartment of Gastroenterology, Brigham and Women Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9704-248X
Paula DenoyaDepartment of Surgery, Stony Brook University, Stony Brook, NY, USA.
Rebecca MartinDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-9948-5463
Agnieszka B BialkowskaDepartment of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0000-0003-2127-7714
Semir BeyazCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0003-4730-4012
Scott T MagnessDepartment of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Patrick HearingDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Hwan Keun KimDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0000-0003-2095-9705
Brian S SheridanDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Peter DempseyDepartment of Pediatrics, University of Colorado, Denver, CO, USA.ORCID http://orcid.org/0000-0003-4151-799X
Pawan KumarDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA. pawan.kumar@stonybrook.edu.ORCID http://orcid.org/0000-0003-3628-452X

Funding

IRACDA - The New York Consortium for the Advancement of Postdoctoral Scholars (NY CAPS)Phase IIK12GM102778 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Carol A. Carter, Karian Janice Wright · 2012 to 2026
$13.1M
Intestinal IL-17RA signaling and mucosal host defenseR01DK121798 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI KUMAR, PAWAN · 2019 to 2023
$2.1M
NIDDK NIH HHS R01 DK121798NIGMS NIH HHS K12 GM102778
6 · The paper itself

Abstract

Paneth cells and their antimicrobial products are critical in mediating small intestinal host defense under homeostatic conditions and after injury or infection. In addition, Paneth cells have also been shown to gain stem-like properties and repropagate intestinal crypts after intestinal injury. The specific role of intestinal IL-17A or its receptor (IL-17RA) signaling in Paneth cells to gain stem-like features has yet to be investigated. Using Paneth cell-specific IL-17RA (Il17ra

Indexed as

ADAM17 ProteinCell DedifferentiationIntestinal MucosaPaneth CellsReceptors, Interleukin-17RegenerationStem CellsAnimalsInterleukin-17MaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionADAM17 ProteinAdam17 protein, mouseIl17a protein, mouseIl17ra protein, mouseInterleukin-17Receptors, Interleukin-17

Identifiers

PMID41844615
PMCPMC13144450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.