Evidence map›Paper›PMID 41844605›Full record

ArticleNature communications2026

Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model.

Zhihua Ou, Zhaoyang Wang, Qi Chen, Peidi Ren, Xiuju He, Yan Liang, Ying'an Liang, Jiaxuan Wang, Sha Liao, Dexin Wang and 12 more

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Zhihua Ou *State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.ORCID http://orcid.org/0000-0002-1479-9007
Zhaoyang Wang *New Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Beijing Key Laboratory of Viral Infectious Diseases, Tsinghua University, Beijing, China.
Qi Chen *Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI Research, Shenzhen, China.
Peidi Ren *Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI Research, Shenzhen, China.
Xiuju He *Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI Research, Shenzhen, China.
Yan LiangNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Beijing Key Laboratory of Viral Infectious Diseases, Tsinghua University, Beijing, China.
Ying'an LiangShenzhen Key Laboratory of Unknown Pathogen Identification, BGI Research, Shenzhen, China.
Jiaxuan WangShenzhen Key Laboratory of Unknown Pathogen Identification, BGI Research, Shenzhen, China.
Sha LiaoBGI Research, Shenzhen, China.
Dexin WangShenzhen Key Laboratory of Unknown Pathogen Identification, BGI Research, Shenzhen, China.
Jie ZhaoBGI Research, Shenzhen, China.
Oujia ZhangNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhenyu PengState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.ORCID http://orcid.org/0000-0002-8383-5905
Jianxin SuShenzhen Key Laboratory of Unknown Pathogen Identification, BGI Research, Shenzhen, China.
Wangsheng LiState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.
Guohai HuState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.ORCID http://orcid.org/0000-0003-2756-8328
Ao ChenBGI Research, Chongqing, China.ORCID http://orcid.org/0000-0002-9699-8340
Ziqing DengState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.ORCID http://orcid.org/0000-0001-8726-0160
Xin JinState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.ORCID http://orcid.org/0000-0001-7554-4975
Xun XuState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.ORCID http://orcid.org/0000-0002-5338-5173
Junhua LiState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China. lijunhua@genomics.cn.ORCID http://orcid.org/0000-0001-6784-1873
Gong ChengNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Beijing Key Laboratory of Viral Infectious Diseases, Tsinghua University, Beijing, China. gongcheng@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0001-7447-5488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cellular interactions that drive the neuropathology of most neuroinvasive viruses remain elusive. We used Japanese encephalitis virus (JEV) to infect female BALB/c mice and applied Stereo-seq to simultaneously capture host and viral transcriptomes in situ, thereby constructing a comprehensive spatiotemporal atlas of Japanese encephalitis (JE) pathogenesis. Our analysis pinpoints Ly6c2

Indexed as

Cell CommunicationEncephalitis, JapaneseEncephalitis Virus, JapaneseAnimalsAntigens, LyBlood-Brain BarrierBrainDisease Models, AnimalDisease ProgressionEndothelial CellsFemaleInterferon-gammaMiceMice, Inbred BALB CMonocytesSpatial TranscriptomicsAntigens, LyInterferon-gamma

Identifiers

PMID41844605
PMCPMC13144672

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.