Evidence map›Paper›PMID 41844556›Full record

ArticleJournal of cellular and molecular medicine2026

DMRTA2 Regulates Radial Glial Maintenance and Tumorigenicity of Paediatric High-Grade Glioma.

Hitomi N Royston, Autumn B Hampton, Elissa G Oliver, Jayden Jackson, Ibukunoluwa Tella, Miriam D Emerson, Dhruv Bhagat, Grace E Zimmerman, Daijiro Konno, Kosuke Funato

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hitomi N RoystonCenter for Molecular Medicine, University of Georgia, Athens, Georgia, USA.
Autumn B HamptonCenter for Molecular Medicine, University of Georgia, Athens, Georgia, USA.
Elissa G OliverCenter for Molecular Medicine, University of Georgia, Athens, Georgia, USA.
Jayden JacksonCenter for Molecular Medicine, University of Georgia, Athens, Georgia, USA.
Ibukunoluwa TellaInstitute of Bioinformatics, University of Georgia, Athens, Georgia, USA.
Miriam D EmersonCenter for Molecular Medicine, University of Georgia, Athens, Georgia, USA.
Dhruv BhagatCenter for Molecular Medicine, University of Georgia, Athens, Georgia, USA.
Grace E ZimmermanCenter for Molecular Medicine, University of Georgia, Athens, Georgia, USA.
Daijiro KonnoCellular and Molecular Bioengineering Laboratory, Graduate School of Science and Engineering, Kindai University, Osaka, Japan.
Kosuke FunatoCenter for Molecular Medicine, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-2437-1116

Funding

Developmental Programs as Vulnerabilities in H3.3G34-Mutant High-Grade GliomaR01NS131659 · NINDS · UNIVERSITY OF GEORGIA · PI Kosuke Funato · 2024 to 2026
$1.0M
NINDS NIH HHS R01 NS131659NINDS NIH HHS R01NS131659
6 · The paper itself

Abstract

DMRTA2 is a member of the evolutionarily conserved transcription factor family involved in various developmental processes including neurogenesis. However, the roles of DMRTA2 in human development and disease are not fully characterised. Single cell RNA-seq data analysis showed that DMRTA2 is robustly expressed in neural progenitors, in particular radial glial (RG) cells, in the human fetal brain. Knockout of the DMRTA2 gene in human embryonic stem cell (hESC)-derived cerebral organoids led to smaller organoid size and fewer RG cells. We also found that DMRTA2 is highly and specifically expressed in diffuse hemispheric gliomas, H3G34-mutant (DHG-H3G34), a malignant subtype of paediatric brain tumour. Loss of DMRTA2 resulted in enhanced neuronal differentiation, fewer RG-like glioma cells and impaired tumorigenicity, suggesting its important role in both normal brain development and the formation of malignant brain tumours.

Indexed as

Brain NeoplasmsCarcinogenesisEpendymoglial CellsGliomaTranscription FactorsAnimalsCell DifferentiationChildGene Expression Regulation, NeoplasticHumansNeoplasm GradingNeurogenesisTranscription Factors

Identifiers

PMID41844556
PMCPMC13098098

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.