ArticleThe Pediatric infectious disease journal2026
Small Epidemic Outbreak of Norovirus in the Pediatric Department of Brescia Civic Hospital (Northern Italy): Genomic Characterization and Phylogenetic Analysis.
Article in The Pediatric infectious disease journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman noroviruses are a leading cause of acute gastroenteritis worldwide, with GII.4 Sydney 2012 [P16], being the predominant circulating genotype in Italy in recent years. Outbreaks in pediatric hospital wards represent a major public health concern.
methodsEight stool samples collected between November 2023 and February 2024 at Brescia Civic Hospital were analyzed by real-time polymerase chain reaction, sequence-independent single-primer amplification and next-generation sequencing.
resultsAll isolates belonged to GII.4 Sydney 2012 [P16] genotype. Five isolates from December 2023 clustered tightly together, confirming a nosocomial outbreak with near-complete sequence identity. Isolates from November 2023, January 2024 and February 2024 were phylogenetically distinct, with 1 isolate (January 2024) clustering in a completely separated tree portion, carrying 30 amino acid substitutions and 237 synonymous mutations.
conclusionsOur analysis confirmed a nosocomial outbreak and underscored the substantial intra-genotypic diversity of GII.4 Sydney 2012 [P16] genotype. These findings highlight the importance of rapid diagnosis, infection control measures and continuous genomic surveillance to track the evolution and global circulation of epidemic noroviruses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.