Breath-by-breath quantification of inhaled nitric oxide absorption and modeling of methemoglobin kinetics.

Run Dong, Hatus V Wanderley, Elisa Mereto, Bijan Safaee Fakhr, Roberto Nardini, Binglan Yu, Lorenzo Berra

Abstract read

In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Beyond vasodilation: reframing inhaled nitric oxide as a precision therapy.American journal of respiratory and critical care medicine · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Run DongAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Medical Intensive Care Unit, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Hatus V WanderleyAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Biomedical Engineering, Department of Anesthesia, Critical Care and Pain Medicine, 17 Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

Elisa MeretoAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Bijan Safaee FakhrAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Roberto NardiniAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

Binglan YuAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Lorenzo BerraAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Respiratory Care Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: lberra@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies uncovered extrapulmonary effects of inhaled nitric oxide (NO) therapy. However, no method exists to quantify NO absorption. This study developed a breath-by-breath system for inhaled NO absorption measurement, which consists of a rapid chemiluminescent NO analyzer and a pneumotachograph. The accuracy of the system was validated in vitro and in an animal model, achieving excellent agreement with the reference gas-collection method (linear regression R

Indexed as

MethemoglobinNitric OxideAdministration, InhalationAnimalsBreath TestsFemaleHumansKineticsSwineMethemoglobinNitric OxideExtrapulmonary effectInhaled nitric oxide therapyMethemoglobin kineticsNitric oxide absorptionPoint-of-care marker

Identifiers

PMID41844498

DOI10.1016/j.redox.2026.104125

PMCPMC13010950

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.