Evidence map›Paper›PMID 41844357›Full record

ArticleCancer medicine2026

Impacts of Neighborhood Persistent Poverty and Socioeconomic Status on Hepatocellular Carcinoma Outcomes: A Large Population-Based Cohort Study.

Mohamed I Elsaid, Holli A Loomans-Kropp, Yesung Kweon, Vinod K Rustgi, Cecilia Dapino, Jesse J Plascak, Samilia Obeng-Gyasi, Chyke Doubeni, Na Li, Khalid Mumtaz and 1 more

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Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Mohamed I ElsaidDivision of Biostatistics and Population Health, Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-7963-2438
Holli A Loomans-KroppCancer Control, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Yesung KweonCenter for Biostatistics, The Ohio State University, Columbus, Ohio, USA.
Vinod K RustgiDivision of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
Cecilia DapinoCase Western Reserve University, Cleveland, Ohio, USA.
Jesse J PlascakCancer Control, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Samilia Obeng-GyasiDivision of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center and James Cancer Hospital, Columbus, Ohio, USA.
Chyke DoubeniDepartment of Family and Community Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Na LiDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, College of Medicine, the Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-5897-3214
Khalid MumtazDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, College of Medicine, the Ohio State University, Columbus, Ohio, USA.
Electra D PaskettCancer Control, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Funding

NCI NIH HHS 1L60CA305768-01
6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) survival in the United States varies sharply by neighborhood disadvantage.

aimTo determine whether residence in persistently impoverished or low-SES census tracts is independently associated with lower all-cause and HCC-specific survival.

methodsWe identified 51,323 adults with HCC using a population-based retrospective cohort from the Surveillance, Epidemiology, and End Results Research Plus Specialized Database (2006-2020). Two census tract-level socioeconomic exposures were defined: persistent poverty (≥ 20% living below the poverty line for approximately 30 years) and low SES (Yost Index first quintile). Overlap Propensity Score Weighting, combined with marginal structural models, estimated the 1-, 5-, 10-, and 15-year risks of all-cause and HCC-specific mortality.

resultsThe median follow-up was 16 months, 6058 (11.8%) lived in persistently impoverished tracts, and 9863 (19.5%) lived in low-SES tracts. After weighting, residents of persistently impoverished areas had a 1-year all-cause mortality risk of 46.0% vs. 40.3% (RD, 5.6%; 95% CI, 4.4% to 6.9%; RR, 1.14; 95% CI, 1.11 to 1.17) and an HCC-specific mortality risk of 33.3% vs. 28.6% (RD, 4.8%; 95% CI, 3.2% to 6.3%; RR, 1.17; 95% CI, 1.11 to 1.22). Living in low-SES tracts raised 1-year all-cause mortality risk to 32.5% vs. 30.1% (RD, 4.8%; 95% CI, 3.6% to 6.0%; RR, 1.12; 95% CI, 1.09 to 1.15) and HCC-specific mortality risk to 32.5% vs. 30.1% (RD, 2.5%; 95% CI, 1.4% to 3.5%; RR, 1.08; 95% CI, 1.05 to 1.12).

conclusionsBoth persistent neighborhood poverty and contemporary low SES independently contribute to significant increases in mortality risk after HCC diagnosis.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNeighborhood CharacteristicsPovertyResidence CharacteristicsSocial ClassAdultAgedFemaleHumansLow Socioeconomic StatusMaleMiddle AgedRetrospective StudiesSEER ProgramSocioeconomic Disparities in Healthcausal inferencehealth disparitiesliver cancersocial determinants of healthsurvival analysis

Identifiers

PMID41844357
PMCPMC13093718

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.