ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2026
Oxygen Supplemented via Face Mask Counteracts Hypoxemia in Capuchin Monkeys (Sapajus spp.) under Butorphanol-Ketamine-Midazolam Restraint.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This prospective, randomized, complete crossover study evaluated the effects of supplemental oxygen on arterial oxygenation and recovery quality in adult capuchin monkeys (Sapajus spp.; n = 8; 6 males and 2 females) chemically restrained with intramuscular butorphanol (0.5 mg/kg), ketamine (15 mg/kg), and midazolam (1 mg/kg). Each monkey underwent 2 anesthetic events, separated by a 2-week interval: one breathing room air (GAIR) and one receiving oxygen via face mask at 3 L/min (GOXY), both conducted during dorsal recumbency. Heart rate (HR), respiratory rate (RR), peripheral oxygen saturation (SpO2), and rectal temperature were registered every 10 minutes for 45 minutes. Arterial blood gases were analyzed at 10 and 30 minutes postrestraint, with oxygen supplementation in GOXY initiated after the 10-minute time point and maintained for 35 minutes. Recovery was continuously video-recorded for later assessment of time to standing and recovery quality by one blinded and one nonblinded observer. At 10 minutes, 14 of 16 monkeys exhibited hypoxemia (partial pressure of arterial oxygen [PaO2] range: 48-81 mm Hg). By 30 minutes, PaO2 and arterial oxygen saturation (SaO2) increased significantly in GOXY, reaching 298-458 mm Hg and 100%, respectively, whereas GAIR animals remained hypoxemic (47-70 mm Hg and ≤92%, respectively). Pulse oximetry-derived SpO2 consistently overestimated saturation at low SaO2 values. The partial pressure of carbon dioxide (PaCO2) rose significantly in GOXY, with hypercapnia (PaCO2 range: 33-57 mm Hg) documented in 6/8 individuals at 30 minutes. In contrast, no cases of hypercapnia were observed in GAIR (PaCO2 range: 22-45 mm Hg) at the same time point. No significant between-group differences were detected in SpO2, HR, RR, or temperature over time. Time to standing and recovery quality were similar between groups. Supplemental oxygen via face mask effectively corrected hypoxemia in Sapajus spp. chemically restrained with butorphanol, ketamine, and midazolam.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.