Evidence map›Paper›PMID 41844›Full record

ArticleThe Journal of cell biology1979

pH regulates the polymerization of actin in the sea urchin egg cortex.

D A Begg, L I Rebhun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 1979. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. AMPK: a cellular metabolic and redox sensor. A minireview.Frontiers in bioscience (Landmark edition) · 2014
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Calcium-responsive contractility during fertilization in sea urchin eggs.Developmental dynamics : an official publication of the American Association of Anatomists · 2006
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

D A Begg
L I Rebhun

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The state of actin in the isolated cortex of the unfertilized sea urchin egg can be controlled by experimentally manipulating the pH of the isolation medium. Cortices isolated at the pH of the unfertilized egg (6.5--6.7) do not contain filamentous actin, while those isolated at the pH of the fertilized egg (7.3--7.5) develop large numbers of microvilli which contain bundles of actin filaments. Cortices that are isolated at pH 6.5 and then transferred to isolation medium buffered at pH 7.5 also develop actin filaments. However, the filaments are not arranged in bundles and microvilli do not form. Although the cortical granules in cortices isolated at pH 6.5 discharge at a free Ca++ concentration of approximately 10 micrometer, actin polymerization is not induced by increasing the Ca++ concentration of the isolation medium. These results suggest that the increase in cytoplasmic pH which occurs following fertilization induces the polymerization of actin in the egg cortex.

Indexed as

Hydrogen-Ion ConcentrationActinsAnimalsCalciumCytoskeletonDose-Response Relationship, DrugFemaleMacromolecular SubstancesMicroscopy, ElectronOvumSea UrchinsActinsCalciumMacromolecular Substances

Identifiers

PMID41844
PMCPMC2110437

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.