Synthesis in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Felipe González-SeguelDepartment of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.ORCID 0000-0001-9099-2389
Owen GustafsonNursing, Midwifery and Allied Health Professions Research and Innovation, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.ORCID 0000-0002-5450-3696
Cayla M RobinsonMedical Center Library, University of Kentucky, Lexington, Kentucky, United States.ORCID 0000-0002-8197-7221
Cecilia VillablancaSchool of Physical Therapy, Faculty of Medicine, Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Catalina OlaveSchool of Physical Therapy, Faculty of Medicine, Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Felipe Muñoz-MuñozSchool of Physical Therapy, Faculty of Medicine, Clínica Alemana Universidad del Desarrollo, Santiago, Chile.ORCID 0000-0003-3570-5193
Camilo Caceres-ParraSchool of Physical Therapy, Faculty of Medicine, Clínica Alemana Universidad del Desarrollo, Santiago, Chile.ORCID 0000-0002-1154-2097
Selina M ParryDepartment of Physiotherapy, School of Health Sciences, The University of Melbourne, Melbourne, Australia.ORCID 0000-0003-2204-3143
Yuan WenCenter for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.ORCID 0000-0002-3210-1629
Esther E Dupont-VersteegdenDepartment of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.ORCID 0000-0001-5576-9659
Kirby P MayerDepartment of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.ORCID 0000-0003-3844-3846
Funding
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Muscle and physical function recovery after acute critical illnessR01AR081002 · NIAMS · UNIVERSITY OF KENTUCKY · PI Esther E Dupont-Versteegden · 2023 to 2026
$1.7M
Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical IllnessK23AR079583 · NIAMS · UNIVERSITY OF KENTUCKY · PI Kirby P Mayer · 2022 to 2026
$744k
AI and Val Rosenstrauss FellowshipHHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001998HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 5R01AR081002HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K23-AR079583HHS | NIH | National Institute of General Medical Sciences (NIGMS) 5R01AR081002NCATS NIH HHS UL1 TR001998NIAMS NIH HHS K23 AR079583NIAMS NIH HHS R01 AR081002NIHR | NIHR Oxford Biomedical Research Centre (OxBRC)NIMHD NIH HHS L32 MD017732
6 · The paper itself
Abstract
Revealing biological mechanisms leading to respiratory muscle dysfunction is essential to improve clinical outcomes in patients with critical illness. The purpose was to identify biological mechanisms associated with respiratory muscle dysfunction in patients with critical illness during mechanical ventilation or sepsis. Six databases were electronically searched from inception to January 2025, examining studies with muscle biopsies. Screening, data collection, and risk-of-bias were conducted in duplicate by two independent assessors. Meta-analysis was performed to determine differences in muscle biological parameters of patients with critical illness requiring mechanical ventilation compared with controls. From 22,036 titles screened, eight studies (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Respiratory muscle dysfunction in mechanical ventilation: a systematic review and meta-analysis of biological mechanisms. · full record | OpenQuestion