ReviewAmerican journal of physiology. Cell physiology2026
The cellular basis of fibrotic tendon healing: now in higher definition.
Review in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Management of Musculoskeletal Injuries with an Inflammatory Damage-Associated Molecular Pattern (DAMP) Etiology.Pain and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Tendon injuries are common and heal through the formation of a fibrotic scar rather than regeneration. This poor natural healing results in impaired function and increases the risk of reinjury. In 2019, we reviewed the current state of the field's understanding of the cellular basis of fibrotic tendon healing, focusing on the resident and infiltrating cell populations that appear at key stages and what was known about their role in tendon healing at the time. Since then, advances in transcriptomic technologies and widespread adoption of lineage tracing have refined our understanding of these processes. This updated review reexamines the key cellular players in tendon healing and summarizes new studies into their origins, dynamics, and potential interactions during healing. Specifically, we highlight recent insights into peripheral compartmental complexity, fibroblast heterogeneity, the emerging role of the adaptive immune system, and potential cellular cross talk in both tendon homeostasis and healing. We also discuss potential therapeutic targets aimed at modulating cell behavior to reduce fibrosis while promoting tendon regeneration and highlight new gaps in knowledge that are critical for continued progress in the field. This review serves as an updated guide to understanding the cellular drivers of fibrotic tendon healing and for informing the development of new therapeutic strategies to improve tendon healing outcomes.
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Registered trials
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