Evidence map›Paper›PMID 41843682›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

SEL1L-HRD1 ERAD-autophagy interplay maintains mitochondrial homeostasis in brown adipocytes.

Xinxin Chen, Siwen Wang, Mauricio Torres, Sijie Hao, Shengyi Sun, Ling Qi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinxin Chen *Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903.
Siwen Wang *Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Mauricio TorresDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903.
Sijie HaoAdvanced Microscopy Facility, University of Virginia School of Medicine, Charlottesville, VA 22903.ORCID 0000-0002-0303-2492
Shengyi SunDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22903.ORCID 0000-0002-1734-3902
Ling QiDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903.ORCID 0000-0001-8229-0184

Funding

Interplay Between SERPINB1 and TLR2/TLR4 in Beta Cell RegenerationR01DK117639 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARVAN, PETER, KULKARNI, ROHIT N. · 2019 to 2023
$3.0M
Regulation of Mitochondrial Dynamics by ERAD: Administrative SupplementR35GM130292 · NIGMS · UNIVERSITY OF VIRGINIA · PI QI, LING · 2019 to 2023
$2.5M
The Role of Sel1L and ER Quality Control in AdipocytesR01DK105393 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI QI, LING · 2015 to 2018
$1.4M
A central role of SEL1L-HRD1 ERAD in LPL maturation in adipocytesR01DK137794 · NIDDK · UNIVERSITY OF VIRGINIA · PI Ling Qi · 2024 to 2026
$1.2M
American Diabetes Association (ADA) 11-23-PDF-62HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1R01DK120047HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK117639HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM130292NIDDK NIH HHS R01 DK105393NIDDK NIH HHS R01 DK137794
6 · The paper itself

Abstract

Mitochondrial integrity is central to energy homeostasis, particularly in brown adipose tissue where dynamic remodeling fuels thermogenesis. Two major proteostatic systems, the SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) pathway and autophagy, have been shown to intersect in vitro, but their physiological coordination in metabolically active tissues remains unclear. Here, we demonstrate that ERAD and autophagy act in synergy to safeguard mitochondrial integrity in brown adipocytes. Using various adipocyte-specific knockout (KO) mouse models and high-resolution ultrastructural 2D and 3D imaging, we show that simultaneous deletion of

Indexed as

Adipocytes, BrownAutophagyEndoplasmic Reticulum-Associated DegradationMitochondriaProteinsUbiquitin-Protein LigasesAnimalsAutophagy-Related Protein 7Endoplasmic ReticulumHomeostasisIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutMitochondria Associated MembranesThermogenesisAtg7 protein, mouseAutophagy-Related Protein 7Intracellular Signaling Peptides and ProteinsProteinsSel1h protein, mouseSyvn1 protein, mouseUbiquitin-Protein Ligases3D FIB-SEMbrown adipocytesER–mitochondrial contactsmegamitochondriathermogenesis

Identifiers

PMID41843682
PMCPMC13012103

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.