Evidence map›Paper›PMID 41843582›Full record

ArticleACS chemical neuroscience2026

Structure-Dependent Antioxidant Activity of Ibogalogs: Impact of Methoxy Group Position on the Protective Activity in Model and Synaptosomal Lipid Membranes.

Paulina Kazmierska-Grebowska, Jacek Grebowski, Michał Żebrowski, Gino A DiLabio, Oskar Ciesielski, Aneta Balcerczyk, Hugo R Arias, Grzegorz Litwinienko

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Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paulina Kazmierska-GrebowskaDepartment of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska Str. 141/143, Lodz 90-236, Poland.
Jacek GrebowskiDepartment of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska Str.141/143 90-236, Lodz, Poland.ORCID 0000-0001-5407-9533
Michał ŻebrowskiFaculty of Chemistry, University of Warsaw, Pasteura Str.1, Warsaw 02-093, Poland.ORCID 0009-0003-6781-165X
Gino A DiLabioDepartment of Chemistry, The University of British Columbia, 3247 University Way, Kelowna, British Columbia V1 V 1 V7, Canada.ORCID 0000-0002-3778-3892
Oskar CiesielskiDepartment of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska Str.141/143 90-236, Lodz, Poland.
Aneta BalcerczykDepartment of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska Str.141/143 90-236, Lodz, Poland.
Hugo R AriasDepartment of Pharmacology and Physiology, Oklahoma State University, College of Osteopathic Medicine, Tahlequah, Oklahoma 74464, United States.
Grzegorz LitwinienkoFaculty of Chemistry, University of Warsaw, Pasteura Str.1, Warsaw 02-093, Poland.ORCID 0000-0002-5523-0888

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indole-tetrahydroazepine derivatives of iboga alkaloids (ibogalogs) exhibit antidepressant, anxiolytic, promnesic, and antineuropathic effects, mainly via serotonergic targets. However, their physicochemical properties relevant to redox biology, including antioxidant activity and membrane stability, have remained poorly characterized. We investigated the antioxidant properties of three ibogalogs: ibogaminalog (DM506), ibogainalog (IBG), and tabernanthalog (TBG), using model lipid membranes (liposomes), human erythrocytes, and rat hippocampal and cortical synaptosomes exposed to AAPH-induced oxidative stress. Physicochemical descriptors, bond dissociation enthalpies, and ionization potentials were also calculated to assess membrane interactions and the antioxidant potential. All ibogalogs protected erythrocytes by reducing hemolysis, potassium efflux, and malondialdehyde levels, with the strongest effects observed for TBG; none induced hemolysis or K

Indexed as

AntioxidantsSynaptosomesAnimalsErythrocytesHemolysisHippocampusHumansLipid PeroxidationLiposomesMaleOxidative StressRatsRats, WistarStructure-Activity RelationshipAntioxidantsLiposomesantioxidantsbond strengthhemolysisibogalogslipid peroxidationsynaptosomes

Identifiers

PMID41843582
PMCPMC13047532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.