ArticleEmerging microbes & infections2026
Natural history of latent brucellosis and diagnostic performance of B-SPOT: a 24-month prospective cohort study based on large-scale screening in northern China.
Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Whether latent brucellosis exists prior to symptom onset and predisposes individuals to active disease remains to be determined. We established a novel ELISpot method for brucellosis (B-SPOT) based on host-specific immune. Diagnostic efficacy was evaluated in a testing cohort comprising brucellosis and non-brucellosis participants. A large-scale screening, using serum agglutination test (SAT) and B-SPOT for latent brucellosis, was later performed in Kangping, a brucellosis-endemic area in northern China, followed by a 24-month prospective cohort study to observe the natural development of latent brucellosis without any intervention. Among 41 brucellosis and 57 non-brucellosis participants, the sensitivity of B-SPOT for brucellosis was 95.1%, and the specificity was 98.2%, compared to the combination of blood culture and SAT. 2459 residents were screened, and the prevalence of latent brucellosis was 3.3% (81/2459). Among 63 latent brucellosis cases successfully followed, 33.3% (21/63) progressed to acute brucellosis within 2 years, while none in the control group progressed(
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