SynthesisDermatology and therapy2026
Impact of Chronic Nodular Prurigo on Quality of Life: A Systematic Review of the Literature.
Synthesis in Dermatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Literature Review: Recent Therapeutic Advances in The Management of Prurigo Nodularis: From Conventional Therapy to Biologics and Targeted Small-Molecule Agents.Clinical, cosmetic and investigational dermatology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChronic nodular prurigo (CNPG), also known as prurigo nodularis, is an inflammatory neuroimmune skin disorder characterized by intense pruritus and nodular lesions resulting from scratching. CNPG affects patients' health-related quality of life (HRQoL); however, the magnitude of burden and clinical implications remain underrecognized in dermatologic practice.
methodsThis systematic review was conducted in accordance with PRISMA 2020 guidelines. Searches of PubMed and the Cochrane Library (April 2025) identified observational studies reporting HRQoL, symptom burden, or unmet needs in adults with CNPG. Two reviewers independently screened studies, extracted data, and assessed methodological quality using the STROBE checklist.
resultsOf 464 records identified, 23 studies met the inclusion criteria. CNPG was consistently associated with substantial impairment in HRQoL, primarily driven by uncontrolled pruritus. Mean Dermatology Life Quality Index scores ranged from 7 to 22, EQ-5D scores from 57.4 to 65.3, and Health Utilities Index Mark III scores were approximately 0.52, significantly lower than in control population (p < 0.001). Pruritus emerged as the dominant symptom and central determinant of HRQoL impairment, reflected by elevated Itchy Quality of Life, 5-D Itch, and 5-D Pruritus Life Quality scores. Sleep disturbances were reported by up to 100% of patients, while anxiety and depressive symptoms affected 26-46% and 16-57% of patients, respectively. CNPG was associated with impairment in daily activities (up to 100%), occupational functioning (up to 83%), and social or sexual relationships (27-95%). Treatment satisfaction was low (mean 57.4%), and higher pruritus intensity was associated with worse HRQoL and lower satisfaction. However, no mediation analyses were performed, and causal relationships between pruritus severity and HRQoL impairment cannot be established.
conclusionsCNPG is associated with a substantial and multidimensional disease burden extending beyond cutaneous manifestations. Pruritus may emerge as the central driver of this burden, underscoring the importance of systematic assessment of HRQoL and itch severity.
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